Concanavalin A (Con A) induces T-cell-mediated hepatic injury in vivo although Con A-stimulated lymphocytes are not cytotoxic to normal hepatocytes in vitro, This contradiction makes the mechanism of Con A-induced hepatitis elusive. In this study,...
Controversy has surrounded origin and differentiation of tissue macrophages. We directly demonstrate the differentiation of bone marrow cells into macrophages in the liver in vivo using a cell-labeling fluorescence dye, PKH-26. Bone marrow cells l...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 209(1) 335-342 1995年4月
Inflammatory cytokines such as tumor necrosis factor alpha (TNF alpha), interferon gamma (IFN gamma) and interleukin-1 beta (IL-1 beta) play important roles in the mechanisms of hepatitis. The effects of these cytokines on the expression of vascul...
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