International Journal of Herbal Medicine 9(3) 54-60 2021年9月 [査読有り]
Body is always exposed to both endogenous and exogenous oxidative stress, and neutralizes them with antioxidant defense system. Imbalance between oxidant and antioxidant produces reactive oxygen and nitrogen species, causing oxidation of protein, ...
Biochemical and Biophysical Research Communications 529(4) 1073-1079 2020年9月 [査読有り]
DNA methylation is an epigenetic modification that regulates gene transcription. DNA methyltransferase
1 (DNMT1) plays an important role in DNA methylation. However, the involvement of DNMT1 and DNA
methylation in the pathogenesis of atopic dermat...
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 2017 2017年 [査読有り]
Liver resident macrophages designated Kupffer cells (KCs) form the largest subpopulation of tissue macrophages. KCs are involved in the pathogenesis of liver inflammation. However, the role of KCs in the systemic inflammation is still elusive. In ...
Hepatocyte apoptosis plays a key role in the pathogenesis of immune-mediated hepatitis. However, the detailed mechanisms of apoptosis signaling are still unclear and effective therapeutic drugs for hepatitis have been explored. Here, we show that ...