The long-term exposure of mice to superantigen SEA using a mini-osmotic pump (SEA pump) induced a long-lasting expansion of V beta 3(+)CD4(+) T cells with T helper (Th) 2 cell-type properties. Removal of the SEA pump 10 days after pump implantatio...
We previously reported that V beta 3(+) CD4(+) T cells maintained a protracted expansion, with the phenotypes of memory Th2 cells, for 30 days in C57BL/6 (B6) mice implanted with SEA-containing mini-osmotic pumps. In the present Study, we followed...
M Koyanagi A Baguet J Martens R Margueron T Jenuwein M Bix
JOURNAL OF BIOLOGICAL CHEMISTRY 280(36) 31470-31477 2005年9月 [査読有り]
Differentiation of naive CD4 T cells toward the T helper 1 (T(H)1) and T helper 2 (T(H)2) fates involves the transcriptional repression and enhancement, respectively, of Il4 and Il13, adjacent chromosome 11 genes encoding the canonical T(H)2 cytok...
T Miyoshi-Akiyama D Takamatsu M Koyanagi JZ Zhao K Imanishi T Uchiyama
JOURNAL OF INFECTIOUS DISEASES 192(1) 107-116 2005年7月 [査読有り]
We analyzed the in vivo dynamics of peritoneal exudate cells (PECs) in mice injected with group A streptococcus (GAS). A live low-virulence strain, as well as heat-killed low- and high-virulence strains, significantly increased the number of PECs ...
M Koyanagi K Imanishi Y Arimura H Kato J Yagi T Uchiyama
INTERNATIONAL IMMUNOLOGY 16(2) 315-326 2004年2月 [査読有り]
To determine the levels of maturation and differentiation of murine CD4 single-positive (SP) T cells, we compared the secondary responses of staphylococcal enterotoxin A (SEA)-induced neonatal thymic, adult thymic and adult splenic CD4 SP T cell b...
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