獣医保健看護学科

研究キーワード

Zoo animal ,Animal model ,Carcinogenesis

研究分野

ライフサイエンス / 腫瘍診断、治療学 /
ライフサイエンス / 実験病理学 / 腫瘍学
ライフサイエンス / 獣医学 / 病理学

委員歴

2020年4月

-

現在

内閣府食品安全委員会動物用医薬品専門調査会専門委員

2019年10月

-

現在

公益財団法人日本獣医学会評議員

2015年12月

-

現在

環境省ライチョウ保護増殖事業死因解明病理検査担当

受賞

1997年1月

第13回日本毒性病理学会年会長賞

1995年1月

第11回日本毒性病理学会年会長賞

論文

<2 345 6 >

FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic Cancer.

Norihiko Sasaki Fujiya Gomi Hisashi Yoshimura Masami Yamamoto Yoko Matsuda Masaki Michishita Hitoshi Hatakeyama Yoichi Kawano Masashi Toyoda Murray Korc Toshiyuki Ishiwata

Cancers 12(10) 2020年10月 [査読有り]

Fibroblast growth factor receptor 4 (FGFR4), one of four tyrosine kinase receptors for FGFs, is involved in diverse cellular processes. Activation of FGF19/FGFR4 signaling is closely associated with cancer development and progression. In this stud...

Primary Lymphangiosarcoma of the Urinary Bladder in a Dog.

Masaki Michishita Y. Ishizaki Masaki Konnai Yukino Machida Rei Nakahira Hitoshi Hatakeyama Hisashi Yoshimura Masami Yamamoto Satoshi Soeta Kazuhiko Ochiai K. Misawa Naoko Yugeta Daigo Azakami

Journal of comparative pathology 179 31-35 2020年8月 [査読有り]

Abdominal ultrasonographical and computed tomography examinations of a 12-year-old neutered female toy poodle revealed a protruding mass, approximately 2 cm in diameter, at the apex of the bladder. The mass was firm and haemorrhagic with a homogen...

An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells.

Shogo Kumagai Yosuke Togashi Chika Sakai Akihito Kawazoe Masahito Kawazu Toshihide Ueno Eiichi Sato Takeshi Kuwata Takahiro Kinoshita Masami Yamamoto Sachiyo Nomura Tetsuya Tsukamoto Hiroyuki Mano Kohei Shitara Hiroyoshi Nishikawa

Immunity 53(1) 187-203 2020年7月 [査読有り]

Only a small percentage of patients afflicted with gastric cancer (GC) respond to immune checkpoint blockade (ICB). To study the mechanisms underlying this resistance, we examined the immune landscape of GC. A subset of these tumors was characteri...

Alien parasitic infections in the endangered Ryukyu long-furred rat (Diplothrix legata) on Amami-Oshima Island, Japan

Toshihiro Tokiwa Hisashi Yoshimura Keiko Ito Shyun Chou Masami Yamamoto

Parasitology International 76 102058 2020年6月 [査読有り]

Hepatic neuroendocrine carcinoma with metastases to the lymph nodes in a sika deer (Cervus nippon yakushimae).

Ritsu Shibata Yukino Machida Hitoshi Hatakeyama Hisashi Yoshimura Masami Yamamoto Kazuhiko Ochiai Kazuyoshi Uematsu Masaki Michishita

The Journal of veterinary medical science 82(2) 193-196 2020年2月 [査読有り]

A 26-year and 6-month-old male sika deer that was kept at the Showa Park, Tokyo, Japan, collapsed and died of severe disease wasting and severe tabefaction. Grossly, numerous masses, 0.3-1.0 cm diameter, were dispersed throughout the liver. The mu...