Research in veterinary science 133 150-156 2020年9月 [査読有り]
Renal proteinuria is associated with promoted renal dysfunction and a shorter survival period in dogs with chronic kidney disease (CKD). Renin angiotensin- aldosterone system inhibitors are primarily used to treat renal proteinuria. In this retros...
Research in veterinary science 133 106-110 2020年9月 [査読有り]
The effects of different doses of orally administered sildenafil on pulmonary haemodynamics in dogs with pulmonary hypertension (PH) have not been documented in an invasive and quantitative manner. In this study, we examined the effects of oral si...
S Mikawa M Nagakawa H Ogi R Akabane Y Koyama A Sakatani M Ogawa H Miyakawa J Shigemoto T Tokuriki N Toda Y Miyagawa N Takemura
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology 30 92-99 2020年6月 [査読有り]
INTRODUCTION/OBJECTIVES: The American College of Veterinary Internal Medicine (ACVIM) guidelines suggest that pimobendan should be initiated in dogs which meet all criteria of stage B2 myxomatous mitral valve disease (MMVD): murmur intensity ≥ 3/6...
Veterinary research communications 44(2) 73-81 2020年5月 [査読有り]
BACKGROUND: Sildenafil improves autonomic dysfunction caused by pulmonary hypertension (PH) in humans, but its effect is unknown in dogs with PH. This prospective study aimed to evaluate the autonomic nervous system function of a canine model of c...
The Journal of veterinary medical science 82(4) 446-451 2020年4月 [査読有り]
Information regarding the pharmacokinetics of oral sildenafil in dogs with pulmonary hypertension is limited. In this study, we examined the pharmacokinetics of oral sildenafil in a canine model of chronic embolic pulmonary hypertension (CEPH). Th...
学長
獣医学部