獣医学科

委員歴

2015年1月

-

2016年12月

日本細菌学会教育委員

論文

Non-target GC-MS analyses of fecal VOCs in NASH-hepatocellular carcinoma model STAM mice.

Mai Kato Momoka Yamaguchi Akira Ooka Ryota Takahashi Takuji Suzuki Keita Onoda Yuko Yoshikawa Yuta Tsunematsu Michio Sato Yasukiyo Yoshioka Miki Igarashi Sumio Hayakawa Kumiko Shoji Yutaka Shoji Tomohisa Ishikawa Kenji Watanabe Noriyuki Miyoshi

Scientific reports 13(1) 8924-8924 2023年6月

The increased incidence of obesity in the global population has increased the risk of several chronic inflammation-related diseases, including non-alcoholic steatohepatitis (NASH)-hepatocellular carcinoma (HCC). The progression from NASH to HCC in...

Induction of DNA Damage in Mouse Colorectum by Administration of Colibactin-producing Escherichia coli, Isolated from a Patient With Colorectal Cancer

TAKUMI NARITA YUTA TSUNEMATSU NORIYUKI MIYOSHI MASAMI KOMIYA TAKAHIRO HAMOYA GEN FUJII YUKO YOSHIKAWA MICHIO SATO MASANOBU KAWANISHI HARUHIKO SUGIMURA YUJI IWASHITA YUKARI TOTSUKA MASARU TERASAKI KENJI WATANABE KEIJI WAKABAYASHI MICHIHIRO MUTOH

In Vivo 36(2) 628-634 2022年 [査読有り]

Mother-to-infant transmission of the carcinogenic colibactin-producing bacteria.

Yuta Tsunematsu Koji Hosomi Jun Kunisawa Michio Sato Noriko Shibuya Emiko Saito Haruka Murakami Yuko Yoshikawa Yuji Iwashita Noriyuki Miyoshi Michihiro Mutoh Hideki Ishikawa Haruhiko Sugimura Motohiko Miyachi Keiji Wakabayashi Kenji Watanabe

BMC microbiology 21(1) 235-235 2021年8月 [査読有り]

BACKGROUND: The Escherichia coli strain that is known to produce the genotoxic secondary metabolite colibactin is linked to colorectal oncogenesis. Therefore, understanding the properties of such colibactin-positive E. coli and the molecular mecha...

Isolation of New Colibactin Metabolites from Wild-Type Escherichia coli and In Situ Trapping of a Mature Colibactin Derivative.

Tao Zhou Yuichiro Hirayama Yuta Tsunematsu Nanami Suzuki Seiji Tanaka Nahoko Uchiyama Yukihiro Goda Yuko Yoshikawa Yuji Iwashita Michio Sato Noriyuki Miyoshi Michihiro Mutoh Hideki Ishikawa Haruhiko Sugimura Keiji Wakabayashi Kenji Watanabe

Journal of the American Chemical Society 143(14) 5526-5533 2021年4月 [査読有り]

Colibactin is a polyketide-nonribosomal peptide hybrid secondary metabolite that can form interstrand cross-links in double-stranded DNA. Colibactin-producing Escherichia coli has also been linked to colorectal oncogenesis. Thus, there is a strong...

Characterization of colibactin-producing Escherichia coli isolated from Japanese patients with colorectal cancer.

Yuko Yoshikawa Yuta Tsunematsu Nobuo Matsuzaki Yuichiro Hirayama Fumi Higashiguchi Michio Sato Yuji Iwashita Noriyuki Miyoshi Michihiro Mutoh Hideki Ishikawa Haruhiko Sugimura Keiji Wakabayashi Kenji Watanabe

Japanese journal of infectious diseases 73(6) 437-442 2020年5月 [査読有り]

We investigated the relationship between colibactin-producing (clb+) Escherichia coli and colorectal adenocarcinoma. In total, 729 E. coli colonies were isolated from tumor and surrounding non-tumor regions in resected specimens from 34 Japanese p...