Hidenori Kanda Takeharu Kaneda Yuta Nagai Norimoto Urakawa Kazumasa Shimizu
Journal of Veterinary Medical Science 80(5) 846-850 2018年5月 [査読有り]
Exposure to chronic hypoxic conditions causes various gastric diseases, including gastric ulcers. It has been suggested that gastric smooth muscle contraction is associated with aerobic metabolism. However, there are no reports on the association ...
Takeharu Kaneda Hidenori Kanda Tsuyoshi Tajima Norimoto Urakawa Kazumasa Shimizu
Journal of Veterinary Medical Science 80(2) 341-345 2018年2月 [査読有り]
The mechanism of imidazole-induced contraction on the bovine tracheal smooth muscle was investigated. Imidazole induced muscle contraction in a concentration-dependent manner on bovine, porcine and guinea-pig tracheas, but not in rat or mouse. In ...
Journal of Pharmacological Sciences 136(1) 26-30 2018年1月 [査読有り]
Chlorogenic acid (CGA) is a polyphenol found in coffee and medicinal herbs such as Lonicera japonica. In this study, the effect of CGA-induced relaxation on carbachol (CCh)-induced contraction of mouse urinary bladder was investigated. CGA (30–300...
Journal of Veterinary Medical Science 80(3) 499-502 2018年 [査読有り]
The present study was designed to clarify phosphodiesterase 9 (PDE9) expression in bovine tracheal smooth muscle tissue, and to elucidate that PDE9 may contribute to the regulation of airway relaxation. PDE9 mRNA expression was detected in bovine ...
JOURNAL OF VETERINARY MEDICAL SCIENCE 79(3) 593-601 2017年3月 [査読有り]
Recent studies have shown that phloridzin, an inhibitor of sodium glucose cotransporter (SGLT), strongly decreases high K+-induced contraction in phasic muscle, such as tenia coil, but slightly affects tonic muscle, such as trachea. In this study,...
K Shimizu M Ozeki A Iino S Nakajyo N Urakawa M Atsuchi
JAPANESE JOURNAL OF PHARMACOLOGY 86(2) 223-229 2001年6月
The leaves of Gymnema inodorum (GI) have been known to be effective for some diseases including diabetes mellitus, rheumatic arthritis and gout. The crude saponin mixtures extracted from GI leaves inhibited glucose absorption in the isolated intes...
K Shimizu M Ozeki A Iino S Nakajyo N Urakawa M Atsuchi
JAPANESE JOURNAL OF PHARMACOLOGY 86(2) 223-229 2001年6月
The leaves of Gymnema inodorum (GI) have been known to be effective for some diseases including diabetes mellitus, rheumatic arthritis and gout. The crude saponin mixtures extracted from GI leaves inhibited glucose absorption in the isolated intes...
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