Journal of Veterinary Medical Science 80(5) 846-850 2018年5月 [査読有り]
Exposure to chronic hypoxic conditions causes various gastric diseases, including gastric ulcers. It has been suggested that gastric smooth muscle contraction is associated with aerobic metabolism. However, there are no reports on the association ...
Journal of Veterinary Medical Science 80(2) 341-345 2018年2月 [査読有り]
The mechanism of imidazole-induced contraction on the bovine tracheal smooth muscle was investigated. Imidazole induced muscle contraction in a concentration-dependent manner on bovine, porcine and guinea-pig tracheas, but not in rat or mouse. In ...
Journal of Pharmacological Sciences 136(1) 26-30 2018年1月 [査読有り]
Chlorogenic acid (CGA) is a polyphenol found in coffee and medicinal herbs such as Lonicera japonica. In this study, the effect of CGA-induced relaxation on carbachol (CCh)-induced contraction of mouse urinary bladder was investigated. CGA (30–300...
Journal of Veterinary Medical Science 80(3) 499-502 2018年 [査読有り]
The present study was designed to clarify phosphodiesterase 9 (PDE9) expression in bovine tracheal smooth muscle tissue, and to elucidate that PDE9 may contribute to the regulation of airway relaxation. PDE9 mRNA expression was detected in bovine ...
JOURNAL OF VETERINARY MEDICAL SCIENCE 79(3) 593-601 2017年3月 [査読有り]
Recent studies have shown that phloridzin, an inhibitor of sodium glucose cotransporter (SGLT), strongly decreases high K+-induced contraction in phasic muscle, such as tenia coil, but slightly affects tonic muscle, such as trachea. In this study,...
Journal of Smooth Muscle Research 36(3) 83-91 2000年
In the present paper, we examined a mechanism of the papaverine-induced relaxation in the smooth muscle of non-pregnant rat uterus. The hyperosmotic 65 mM KCl (H-65K+)-or oxytocin-induced contraction in the uterus was inhibited by an addition of p...
Japanese Journal of Pharmacology 83(2) 143-149 2000年
In guinea pig urinary bladder, the hyperosmotic 65 mM KCl (H-65K+)- or carbachol (CCh)-induced contraction was inhibited by an addition of papaverine in a concentration-dependent manner. The cAMP content of the muscle in the presence of H-65K+ or ...
T Kaneda   K Shimizu   S Nakajyo   N Urakawa   
EUROPEAN JOURNAL OF PHARMACOLOGY 355(2-3) 149-157 1998年8月
Papaverine (0.3-100 mu M) more potently inhibited phenylephrine (1 mu M)-induced contraction than 65 mM K+-induced contraction of the aorta, while it equally inhibited contractions induced by 65 mM K+ and carbachol (1 mu M) in ileal smooth muscle....
JOURNAL OF VETERINARY MEDICAL SCIENCE 59(9) 753-757 1997年9月
Gymnema sylvestre (GS) is one of the Asclepiad strains that grows in South-east Asia. Their therapeutic effects for treating diabetes mellitus, rheumatic arthritis and gout have been well known for a long time. However, the problem is that GS supp...