JOURNAL OF VETERINARY MEDICAL SCIENCE 77(10) 1201-1206 2015年10月 [査読有り]
G protein-coupled receptor (GPR) 120 is an unsaturated fatty acid receptor, which is associated with various physiological functions. It is reported that the genetic variant of GPR120, p.Arg270His, is detected more in obese people, and this geneti...
Hitomi Oda   Akihiro Mori   Peter Lee   Kaori Saeki   Toshiro Arai   Toshinori Sako   
JOURNAL OF VETERINARY MEDICAL SCIENCE 76(10) 1383-1387 2014年10月 [査読有り]
Sitagliptin is a dipeptidyl peptidase-4 inhibitor aimed at treating Type 2 diabetes mellitus (T2DM) and T1DM, by increasing blood levels of Glucagon-like peptide 1 (GLP-1) and insulin. The objective of this preliminary study is to characterize Sit...
JOURNAL OF VETERINARY MEDICAL SCIENCE 76(8) 1177-1182 2014年8月 [査読有り]
Hyperadrenocorticism (HAC) is a common endocrine disorder in dogs, in which excess glucocorticoid causes insulin resistance. Disturbance of insulin action may be caused by multiple factors, including transcriptional modulation of insulin signal mo...