S. Nakamura   Y. Uenoyama   K. Ikegami   M. Dai   Y. Watanabe   C. Takahashi   M. Hirabayashi   H. Tsukamura   K. -I. Maeda   
JOURNAL OF NEUROENDOCRINOLOGY 28(10) 2016年10月 [査読有り]
Rodents show apparent sex differences in their sexual behaviours. The present study used Kiss1 knockout (KO) rats to evaluate the role of kisspeptin in the defeminisation/masculinisation of the brain mechanism that controls sexual behaviours. Cast...
After the discovery of hypothalamic kisspeptin encoded by the Kiss1 gene, the central mechanism regulating gonadotropin-releasing hormone (GnRH) secretion, and hence gonadotropin secretion, is gradually being unraveled. This has increased our unde...
JOURNAL OF NEUROENDOCRINOLOGY 27(3) 187-197 2015年3月 [査読有り]
Kisspeptin, encoded by the Kiss1 gene, has attracted attention as a key candidate neuropeptide in controlling puberty and reproduction via regulation of gonadotrophin-releasing hormone (GnRH) secretion in mammals. Pioneer studies with Kiss1 or its...
JOURNAL OF NEUROENDOCRINOLOGY 26(12) 909-917 2014年12月 [査読有り]
The oestrogen-induced luteinising hormone (LH) surge is evident in male primates, including humans, whereas male rodents never show the LH surge, even when treated with a preovulatory level of oestrogen. This suggests that the central mechanism go...
JOURNAL OF REPRODUCTION AND DEVELOPMENT 60(4) 312-316 2014年8月 [査読有り]
Puberty is associated with an increase in gonadotropin secretion as a result of an increase in gonadotropin-releasing hormone (GnRH) secretion. Kisspeptin is considered to play a key role in puberty onset in many mammalian species, including roden...