廣瀨 光了

A kinetically controlled self-organization system was realized using the synthetically simple molecule 4,6-O-pyrenylidene glucose (Py-Glc).

Abstract The N-acetyl (NAc) group of N-acetyl glucosamine (GlcNAc) in the core structure of N-glycans is believed to stabilize their folded conformation. In this study, we synthesized Man3GlcNAc2, the common structural motif of N-glycan, bearing NAc groups and Man3Glc2 having no NAc group to understand the differences in their folded conformations due to the presence or absence of NAc group using 2D-NMR analysis. In Man3GlcNAc2, the branched α1-6Man was found to be positioned closer to the core sugar residue compared to Man3Glc2.