Satoru Iwata, Yoshiharu Ishiguro, Masataka Utsugi, Keiryo Mitsuhashi, Kiyoshi Tanaka
Bull. Chem. Soc. Jpn.,, 66(8) 2432-2435, 1993 Peer-reviewedLead author
Additions of various carbanion nucleophiles to 3,3,3-trifluoro-1-nitropropene (1) proceeded regiospecifically at the C-2 position of 1 to give the corresponding adducts. The nitro group of the adducts, derived from the reactions with acetylacetone and ethyl acetoacetate, was reduced to the corresponding amines, which were cyclized in situ to the 3-(trifluoromethyl)pyrrole derivatives.