Kiichiro Totani   Kenta Yamaya   Makoto Hirano   Yukishige Ito   
CARBOHYDRATE RESEARCH 439 16-22 2017年2月 [査読有り]
Glycoprotein N-linked oligosaccharides in the endoplasmic reticulum function as tags to regulate glycoprotein folding, sorting, secretion and degradation. Since the N-glycan structure of a glycoprotein should reflect the folding state, N-glycan pr...
PROTEIN AND PEPTIDE LETTERS 24(8) 723-728 2017年 [査読有り]
Background: Peptide: N-glycanase is a deglycosylation enzyme releasing N-glycan from glycoproteins. Although glycan specificity analysis of this enzyme has been reported, recognition requirements for the peptide sequence have not been precisely el...
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1861(1) 3106-3118 2017年1月 [査読有り]
Background: Megalin is a 600-kDa single-spanning transmembrane glycoprotein and functions as an endocytic receptor, distributed not only in the kidney but also in other tissues. Structurally and functionally distinct ligands for megalin have been ...
Biochimica et biophysica acta. General subjects 1861(1 Pt A) 3106-3118 2017年1月 [査読有り]
BACKGROUND: Megalin is a 600-kDa single-spanning transmembrane glycoprotein and functions as an endocytic receptor, distributed not only in the kidney but also in other tissues. Structurally and functionally distinct ligands for megalin have been ...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 478(1) 247-253 2016年9月 [査読有り]
The metabolic syndrome including obesity and diabetes mellitus is known to be a major health problem worldwide. A recent study reported that obesity causes endoplasmic reticulum (ER) stress and subsequently leads to insulin resistance and type 2 d...