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研究者業績

Researcher List >> Yoshitsugu Shiro
 

Yoshitsugu Shiro

 
Avatar
NameYoshitsugu Shiro
URL
Affiliation兵庫県立大学
Section生命理学研究科 生命科学専攻
Job title教授
DegreePh.D. (Doctor of Engineering)
J-Global ID200901033757880370

Research Interests

 
Iron Transporters ,Nitric Oxide Reducatse ,センサータンパク質 ,酸素添加酵素 ,チトクロムP450 ,金属酵素 ,Sensor proteins ,Oxygenases ,Cytochrome P450 ,Metal-binding enzymes

Research Areas

 
  • Life sciences / Molecular biology / 
  • Life sciences / Functional biochemistry / 
  • Life sciences / Structural biochemistry / 
  • Nanotechnology/Materials / Polymer chemistry / 
  • Nanotechnology/Materials / Basic physical chemistry / 

Research History

123>
 
Apr 2015
 - 
Today
University of Hyogo Graduate School of Life Science Professor 
 
Apr 2016
 - 
Mar 2018
Kyushu University Institute for Materials Chemistry and Engineering  
 
Apr 2000
 - 
Mar 2015
理化学研究所 播磨研究所 生体物理化学研究室 主任研究員 
 
Apr 1999
 - 
Mar 2015
姫路工業大学（現 兵庫県立大学）大学院 生命理学研究科 連携大学院 教授 
 
Apr 2006
 - 
Mar 2013
大阪大学大学院 理学研究科 連携大学院 教授 
 

Education

 
Apr 1980
 - 
Mar 1985
Kyoto University Graduate School of Engineering 
 
Apr 1976
 - 
Mar 1980
Kyoto University Faculty of Engineering Department of Hydrocarbon Chemistry
 

Committee Memberships

 
Jun 2018
 - 
Jun 2020
Vice President
 
Jun 2019
 - 
Jun 2019
Chair
 

Awards

12>
 
Jan 2021
The Chemical Scoiety of Japan, CSJ Award,Molecular Structural and FUnctional Studies on Iron-Related Proteins
 
Nov 2020
Hyogo, Hyogo Scientific Excellence Award
 
Oct 2020
University of Hyogo, 研究活動教員表彰 最優秀研究活動賞
 
Sep 2019
JSCC (Japan Society of Coordination Chemistry), JSCC Contribution Awards,Functional Studies on Hemoproteins Based on Their Molecular Structures: New Era of Integrated Biometal Sciences
 
Mar 2013
RIKEN, 理化学研究所 重要業績表彰
 

Papers

12345>
 
 
細胞内鉄輸送に関わる鉄シャペロンと鉄貯蔵タンパク質の複合体形成の分子機構
佐藤 渚   浦 敦人   簗取 いずみ   當舎 武彦   城 宜嗣   澤井 仁美   
日本生化学会大会プログラム・講演要旨集   96回 [2P-193]   Oct 2023
 
鉄還元機能を持つ6回膜貫通型タンパク質101F6の大腸菌での発現と機能解析
阪口 智哉   澤井 仁美   城 宜嗣   鍔木 基成   當舎 武彦   木村 哲就   杉本 宏   
日本生化学会大会プログラム・講演要旨集   96回 [2P-656]   Oct 2023
 
Trapping of a Mononitrosyl Nonheme Intermediate of Nitric Oxide Reductase by Cryo-Photolysis of Caged Nitric Oxide.
Hanae Takeda   Kanji Shimba   Masaki Horitani   Tetsunari Kimura   Takashi Nomura   Minoru Kubo   Yoshitsugu Shiro   Takehiko Tosha   
The journal of physical chemistry. B   127(4) 846-854   Feb 2023
Characterization of short-lived reaction intermediates is essential for elucidating the mechanism of the reaction catalyzed by metalloenzymes. Here, we demonstrated that the photolysis of a caged compound under cryogenic temperature followed by th...
 
Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases
Yuya Nishida   Sachiko Yanagisawa   Rikuri Morita   Hideki Shigematsu   Kyoko Shinzawa-Itoh   Hitomi Yuki   Satoshi Ogasawara   Ken Shimuta   Takashi Iwamoto   Chisa Nakabayashi   Waka Matsumura   Hisakazu Kato   Chai Gopalasingam   Takemasa Nagao   Tasneem Qaqorh   Yusuke Takahashi   Satoru Yamazaki   Katsumasa Kamiya   Ryuhei Harada   Nobuhiro Mizuno   Hideyuki Takahashi   Yukihiro Akeda   Makoto Ohnishi   Yoshikazu Ishii   Takashi Kumasaka   Takeshi Murata   Kazumasa Muramoto   Takehiko Tosha   Yoshitsugu Shiro   Teruki Honma   Yasuteru Shigeta   Minoru Kubo   Seiji Takashima   Yasunori Shintani   
Nature Communications   13(1) 7591   Dec 2022   [Refereed]
Abstract

Antimicrobial resistance (AMR) is a global health problem. Despite the enormous efforts made in the last decade, threats from some species, including drug-resistant Neisseria gonorrhoeae, continue to rise and would become untreatable. Th...
 
細胞内鉄輸送タンパク質PCBP1における鉄イオンの結合と輸送の分子メカニズム
浦 敦人   簗取 いずみ   城 宜嗣   澤井 仁美   
日本生化学会大会プログラム・講演要旨集   95回 2T05a-05   Nov 2022

Misc.

12345>
 
 
鉄還元機能を持つ6回膜貫通型タンパク質101F6の大腸菌での発現と機能解析
阪口智哉   澤井仁美   城宜嗣   鍔木基成   當舎武彦   木村哲就   杉本宏   
日本生化学会大会(Web)   96th    2023
 
細胞内鉄輸送に関わる鉄シャペロンと鉄貯蔵タンパク質の複合体形成の分子機構
佐藤渚   浦敦人   簗取いずみ   當舎武彦   城宜嗣   澤井仁美   澤井仁美   
日本生化学会大会(Web)   96th    2023
 
ヒト由来二価金属輸送体DMT1の構造解析にむけた精製法の確立
柴田晃利   藤宇将吾   簗取いずみ   西谷雄大   西谷雄大   高原教代   城宜嗣   澤井仁美   澤井仁美   
生体分子科学討論会講演要旨集   48th    2022
 
ヒト腸管細胞モデル系を用いた鉄イオンの吸収を向上させる食品成分の探索とそれらの成分が鉄輸送関連タンパク質に作用する分子機構
高原教代   杉本宏   神戸大朋   城宜嗣   澤井仁美   澤井仁美   
日本生化学会大会(Web)   94th    2021
 
Probing functional and structural differences of quinol dependent Nitric Oxide Reductases’ (qNOR) within a lipidic nanodisc environment
GOPALASINGAM Chai   YAMAOKA Hiroaki   SHIBATA Akitoshi   FUKUMOTO Kouki   SHIGEMATSU Hideki   TOSHA Takehiko   MURAMOTO Kazumasa   SHIRO Yoshitsugu   
日本蛋白質科学会年会プログラム・要旨集   21st    2021

Professional Memberships

12>
 
 
   
 
日本蛋白質学会
 
   
 
日本生物物理学会
 
   
 
日本生化学会
 
   
 
日本化学会
 
   
 
The Protein Science Society of Japan

Research Projects

12345>
 
 
Integrated Biometal Science: Research to Explore Dynamics of Metals in Cellular System
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Project Year: Jun 2019 - Mar 2024
 
Strctural and Functional Dynamics on Proteins Related to Biometal Dynamics
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Project Year: Jun 2019 - Mar 2024
 
Structural Dynamics of Nitric Oxide Reductases Srudied by Time-Resolved Techniques
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
Project Year: Apr 2019 - Mar 2023
 
Molecular Science of NO Dyanmics in Biological System
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (S)
Shiro Yoshitsugu SUGIMOTO Hiroshi TOSHA Takehiko NAKAMURA Hiro HISANO Tamao KUBO Minoru YAGI Kiyoshi 
Project Year: May 2014 - Mar 2019
 
Development of time-resolved spectroscopic systems with micro-flow devices and their application to the molecular mechanism of ABC transporters
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A)
KIMURA TETSUNARI TSUBAKI Motonari SUGIMOTO Hiroshi SHIRO Yoshitsugu HAYASHI Sae ONISHI Kizashi SHIMONAKA Misato FUJII Koichi TAKEDA Hanae 
Project Year: Apr 2015 - Mar 2018
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