The Journal of biological chemistry 105277-105277 2023年9月
Cytochrome c oxidase (CcO) reduces O2 in the O2-reduction site by sequential four-electron donations through the low-potential metal sites (CuA and Fea). Redox-coupled X-ray crystal structural changes have been identified at five distinct sites in...
Antimicrobial resistance (AMR) is a global health problem. Despite the enormous efforts made in the last decade, threats from some species, including drug-resistant Neisseria gonorrhoeae, continue to rise and would become untreatable. Th...
Journal of Biological Chemistry 297(3) 100967-100967 2021年9月 [査読有り]
Mammalian cytochrome c oxidase (CcO) reduces O2 to water in a bimetallic site including Fea3 and CuB giving intermediate molecules, termed A-, P-, F-, O-, E-, and R-forms. From the P-form on, each reaction step is driven by single-electron donatio...
BIN MOHAMAD JAMALI Muhamad Arif   GOPALASINGAM Chai C.   JOHNSON Rachel M.   MUENCH Stephen P   ANTONYUK Svetlana V.   HASNAIN Samar S.   TOSHA Takehiko   MURAMOTO Kazumasa   SHIRO Yoshitsugu