西谷秀男

研究者氏名	西谷秀男

所属	兵庫県立大学
部署	大学院理学研究科　生体情報学II
職名	教授
学位	理学博士(九州大学)
J-Global ID	201801017657794196

研究分野

ライフサイエンス / 分子生物学 /

経歴

12 >

2020年4月

現在

兵庫県立大学大学院理学研究科

2007年4月

現在

兵庫県立大学大学院生命理学研究科教授

1997年

2007年3月

九州大学大学院医学系研究科助教

1993年

1997年

英国ガン研究基金研究所(ICRF) Cell Cycle lab 博士研究員

1991年

1992年

日本学術振興会特別研究員

学歴

九州大学大学院医学系研究科

九州大学大学院理学研究科

京都大学理学部

論文

<8 91011 12 >

Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines

G Xouri Z Lygerou H Nishitani Pachnis, V P Nurse S Taraviras

EUROPEAN JOURNAL OF BIOCHEMISTRY 271(16) 3368-3378 2004年8月 [査読有り]

Licensing origins for replication upon completion of mitosis ensures genomic stability in cycling cells. Cdt1 was recently discovered as an essential licensing factor, which is inhibited by geminin. Over-expression of Cdt1 was shown to predispose ...

Proteolysis of DNA replication licensing factor Cdt1 in S-phase is performed independently of Geminin through its N-terminal region

H Nishitani Z Lygerou T Nishimoto

JOURNAL OF BIOLOGICAL CHEMISTRY 279(29) 30807-30816 2004年7月 [査読有り]

Licensing of replication origins is carefully regulated in a cell cycle to maintain genome integrity. Using an in vivo ubiquitination assay and temperature-sensitive cell lines we demonstrate that Cdt1 in mammalian cells is degraded through ubiqui...

Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding

N Sugimoto Y Tatsumi T Tsurumi A Matsukage T Kiyono H Nishitani M Fujita

JOURNAL OF BIOLOGICAL CHEMISTRY 279(19) 19691-19697 2004年5月 [査読有り]

The current concept regarding cell cycle regulation of DNA replication is that Cdt1, together with origin recognition complex and CDC6 proteins, constitutes the machinery that loads the minichromosome maintenance complex, a candidate replicative h...

Two ubiquitin-conjugating enzymes, UbcP1/Ubc4 and UbcP4/Ubc11, have distinct functions for ubiquitination of mitotic cyclin

H Seino T Kishi H Nishitani F Yamao

MOLECULAR AND CELLULAR BIOLOGY 23(10) 3497-3505 2003年5月 [査読有り]

Cell cycle events are regulated by sequential activation and inactivation of Cdk kinases. Mitotic exit is accomplished by the inactivation of mitotic Cdk kinase, which is mainly achieved by degradation of cyclins. The ubiquitin-proteasome system i...

Caffeine mimics adenine and 2′-deoxyadenosine, both of which inhibit the guanine-nucleotide exchange activity of RCC1 and the kinase activity of ATR

Nishijima H Nishitani H Saito N Nishimoto T

Genes to Cells 8(5) 423-435 2003年5月 [査読有り]