Takahito Sanada Minsoo Kim Hitomi Mimuro Masato Suzuki Michinaga Ogawa Akiho Oyama Hiroshi Ashida Taira Kobayashi Tomohiro Koyama Shinya Nagai Yuri Shibata Jin Gohda Jun-ichiro Inoue Tsunehiro Mizushima Chihiro Sasakawa
NATURE 483(7391) 623-U149 2012年3月 [査読有り]
Many bacterial pathogens can enter various host cells and then survive intracellularly, transiently evade humoral immunity, and further disseminate to other cells and tissues. When bacteria enter host cells and replicate intracellularly, the host ...
Genes to cells : devoted to molecular & cellular mechanisms 16(11) 1071-80 2011年11月 [査読有り]
Removal of the fucose residue from the N-glycans of the Fc portion of immunoglobulin G (IgG) results in a dramatic enhancement of antibody-dependent cellular cytotoxicity (ADCC) through improved affinity for Fcγ receptor IIIa (FcγRIIIa). Here, we ...
JOURNAL OF BIOLOGICAL CHEMISTRY 286(43) 37496-37502 2011年10月 [査読有り]
Proteasomal degradation is mediated through modification of target proteins by Lys-48-linked polyubiquitin (polyUb) chain, which interacts with several binding partners in this pathway through hydrophobic surfaces on individual Ub units. However, ...
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108(36) 14914-14919 2011年9月 [査読有り]
Nakajo-Nishimura syndrome (NNS) is a disorder that segregates in an autosomal recessive fashion. Symptoms include periodic fever, skin rash, partial lipomuscular atrophy, and joint contracture. Here, we report a mutation in the human proteasome su...
JOURNAL OF BIOLOGICAL CHEMISTRY 285(20) 15159-15166 2010年5月
The ubiquitin-proteasome pathway is a major proteolytic system in eukaryotic cells and regulates various cellular processes. The 26 S proteasome, the central enzyme of this pathway, consists of a proteolytic core particle and two 19 S regulatory p...
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理学研究科