Frontiers in chemistry 11 1175443-1175443 2023年6月 [査読有り]
The bacterial mechanosensitive channel of large conductance MscL is activated exclusively by increased tension in the membrane bilayer. Despite many proposed models for MscL opening, its precise mechano-gating mechanism, particularly how the recei...
Ibrahim M Almanjahie   Ramzan Nazim Khan   Robin K Milne   Takeshi Nomura   Boris Martinac   
European biophysics journal : EBJ 48(4) 383-393 2019年5月 [査読有り]
Ion channel data recorded using the patch clamp technique are low-pass filtered to remove high-frequency noise. Almanjahie et al. (Eur Biophys J 44:545-556, 2015) based statistical analysis of such data on a hidden Markov model (HMM) with a moving...
Tension in cell membranes is closely related to various cellular events, including cell movement and morphogenesis. Therefore, modulation of membrane tension can be a new approach for manipulating cellular events. Here, we show that an amphipathic...
Navid Bavi   Adam D. Martinac   D. Marien Cortes   Omid Bavi   Pietro Ridone   Takeshi Nomura   Adam P. Hill   Boris Martinac   Eduardo Perozo   
The large conductance mechanosensitive channel (MscL), acts as an osmoprotective emergency valve in bacteria by opening a large, water- filled pore in response to changes in membrane tension. In its closed configuration, the last 36 residues at th...
The detailed single-channel gating kinetics of mouse pannexin 1 (mPanx1) remains unknown, although mPanx1 is reported to be a voltage-activated anion-selective channel. We investigated characteristics of single-channel conductances and opening and...
The bacterial MscL (mechanosensitive channel of large conductance) is one of the best studied Mechanosensitive (MS) channels owing to its resolved 3D structure by X-ray crystallography. In addition MscL is known to be activated solely by tension i...
Charles G. Cranfield, Anna Kloda, Yury A. Nikolaev, Adam D. Martinac, Pietro Ridone, Navid Bavi, Omid Bavi, Evgeny Petrov, Andrew R. Battle, Takeshi Nomura, Paul R. Rohde, Yoshitaka Nakayama, Kadla R. Rosholm, Charles D. Cox, Matthew A. Baker and Boris Martinac(担当:分担執筆)