Deficiencies in mitochondrial protein import are associated with a number of diseases. However, although nonimported mitochondrial proteins are at great risk of aggregation, it remains largely unclear how their accumulation causes cell dysfunction...
The Journal of Biochemistry 173(4) 317-326 2023年1月 [査読有り]
Summary
Pathogenic bacteria deliver virulence factors called effectors into host cells in order to facilitate infection. The Shigella effector proteins IpaH1.4 and IpaH2.5 are members of the “novel E3 ligase” (NEL)-type bacterial E3 ligase famil...
Impaired proteasome activity due to genetic variants of certain subunits might lead to proteasome-associated autoinflammatory syndromes (PRAAS). Here we report a de novo heterozygous missense variant of the PSMB9 proteasome subunit gene in two unr...
Yuta Horie Takafumi Suzuki Jin Inoue Tatsuro Iso Geoffrey Wells Terry W Moore Tsunehiro Mizushima Albena T Dinkova-Kostova Takuma Kasai Takashi Kamei Seizo Koshiba Masayuki Yamamoto
The Keap1-Nrf2 system is central for mammalian cytoprotection against various stresses and a drug target for disease prevention and treatment. One model for the molecular mechanisms leading to Nrf2 activation is the Hinge-Latch model, where the DL...
JOURNAL OF BIOLOGICAL CHEMISTRY 285(20) 15159-15166 2010年5月
The ubiquitin-proteasome pathway is a major proteolytic system in eukaryotic cells and regulates various cellular processes. The 26 S proteasome, the central enzyme of this pathway, consists of a proteolytic core particle and two 19 S regulatory p...
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理学研究科