OSW-1 is a plant-derived natural product proposed to selectively kill cancer cells by binding to members of the oxysterol binding protein family, thereby disrupting lipid/sterol homeostasis. However, how these protein-ligand interactions mediate c...
Mai Taniguchi Kanae Sasaki-Osugi Masaya Oku Shogo Sawaguchi Soichiro Tanakura Yumeto Kawai Sadao Wakabayashi Hiderou Yoshida
CELL STRUCTURE AND FUNCTION 41(2) 93-104 2016年 [査読有り]
The Golgi stress response is a homeostatic mechanism that controls the capacity of the Golgi apparatus in accordance with cellular demands. When the capacity of the Golgi apparatus becomes insufficient (Golgi stress), transcription levels of Golgi...
JOURNAL OF BIOCHEMISTRY 157(4) 185-195 2015年4月 [査読有り]
Organelle autoregulation is a homeostatic mechanism to regulate the capacity of each organelle according to cellular demands. The endoplasmic reticulum (ER) stress response increases the expression of ER chaperones and ER-associated degradation fa...
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16(2) 3677-3699 2015年2月 [査読有り]
ALG-2, a 22-kDa penta-EF-hand protein, is involved in cell death, signal transduction, membrane trafficking, etc., by interacting with various proteins in mammalian cells in a Ca2+-dependent manner. Most known ALG-2-interacting proteins contain pr...
大学本部
理学研究科