BIOMED RESEARCH INTERNATIONAL 2016 2401657-2401657 2016年 [査読有り]
MscS (mechanosensitive channel of small conductance) is ubiquitously found among bacteria and plays a major role in avoiding cell lysis upon rapid osmotic downshock. The gating of MscS is modulated by voltage, but little is known about how MscS se...
Takeshi Nomura   Charles D. Cox   Navid Bavi   Masahiro Sokabe   Boris Martinac   
FASEB JOURNAL 29(10) 4334-4345 2015年10月 [査読有り]
The bacterial mechanosensitive channel of small conductance (MscS) plays a crucial role in the protection of bacterial cells against hypo-osmotic shock. The functional characteristics of MscS have been extensively studied using liposomal reconstit...
Ibrahim M Almanjahie   R Nazim Khan   Robin K Milne   Takeshi Nomura   Boris Martinac   
European biophysics journal : EBJ 44(7) 545-56 2015年10月 [査読有り]
The gating behaviour of a single ion channel can be described by hidden Markov models (HMMs), forming the basis for statistical analysis of patch clamp data. Extensive improved bandwidth (25 kHz, 50 kHz) data from the mechanosensitive channel of l...
C. D. Cox   Y. Nakayama   T. Nomura   B. Martinac   
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 467(1) 3-13 2015年1月 [査読有り]
The mechanosensitive channel of small conductance (MscS)-like channel superfamily is present in cell-walled organisms throughout all domains of life (Bacteria, Archaea and Eukarya). In bacteria, members of this channel family play an integral role...
JOURNAL OF PHYSICAL CHEMISTRY B 118(44) 12660-12672 2014年11月 [査読有り]
Patch clamping depends on a tight seal between the cell membrane and the glass of the pipet. Why does the seal have such high electric resistance? Why does the patch adhere so strongly to the glass? Even under the action of strong hydrostatic, adh...
The bacterial MscL (mechanosensitive channel of large conductance) is one of the best studied Mechanosensitive (MS) channels owing to its resolved 3D structure by X-ray crystallography. In addition MscL is known to be activated solely by tension i...
Charles G. Cranfield, Anna Kloda, Yury A. Nikolaev, Adam D. Martinac, Pietro Ridone, Navid Bavi, Omid Bavi, Evgeny Petrov, Andrew R. Battle, Takeshi Nomura, Paul R. Rohde, Yoshitaka Nakayama, Kadla R. Rosholm, Charles D. Cox, Matthew A. Baker and Boris Martinac(担当:分担執筆)