Yong Wang   Yanxin Liu   Hannah A Deberg   Takeshi Nomura   Melinda Tonks Hoffman   Paul R Rohde   Klaus Schulten   Boris Martinac   Paul R Selvin   
eLife 3 e01834 2014年2月 [査読有り]
The mechanosensitive channel of large conductance, which serves as a model system for mechanosensitive channels, has previously been crystallized in the closed form, but not in the open form. Ensemble measurements and electrophysiological sieving ...
Significance: Sensations of touch and hearing are manifestations of mechanical contact and air pressure acting on touch receptors and hair cells of the inner ear, respectively. In bacteria, osmotic pressure exerts a significant mechanical force on...
Shaista Shaikh   Charles D Cox   Takeshi Nomura   Boris Martinac   
Channels (Austin, Tex.) 8(4) 321-6 2014年 [査読有り]
Mechanosensitive (MS) ion channels are molecular sensors that detect and transduce signals across prokaryotic and eukaryotic cell membranes arising from external mechanical stimuli or osmotic gradients. They play an integral role in mechanosensory...
Michael Becker   Kirsten Börngen   Takeshi Nomura   Andrew R Battle   Kay Marin   Boris Martinac   Reinhard Krämer   
Biochimica et biophysica acta 1828(4) 1230-40 2013年4月 [査読有り]
Corynebacterium glutamicum is used in microbial biotechnology for the production of amino acids, in particular glutamate. The mechanism of glutamate excretion, however, is not yet fully understood. Recently, evidence was provided that the NCgl1221...
Evgeny Petrov   Dinesh Palanivelu   Maryrose Constantine   Paul R. Rohde   Charles D. Cox   Takeshi Nomura   Daniel L. Minor   Boris Martinac   
Based on sequence similarity, the sp7 gene product, MscSP, of the sulfur-compound-decomposing Gram-negative marine bacterium Silicibacter pomeroyi belongs to the family of MscS-type mechanosensitive channels. To investigate MscSP channel propertie...
The bacterial MscL (mechanosensitive channel of large conductance) is one of the best studied Mechanosensitive (MS) channels owing to its resolved 3D structure by X-ray crystallography. In addition MscL is known to be activated solely by tension i...
Charles G. Cranfield, Anna Kloda, Yury A. Nikolaev, Adam D. Martinac, Pietro Ridone, Navid Bavi, Omid Bavi, Evgeny Petrov, Andrew R. Battle, Takeshi Nomura, Paul R. Rohde, Yoshitaka Nakayama, Kadla R. Rosholm, Charles D. Cox, Matthew A. Baker and Boris Martinac(担当:分担執筆)