Masahito Watari Tatsuya Ikuta Daichi Yamada Wataru Shihoya Kazuho Yoshida Satoshi P Tsunoda Osamu Nureki Hideki Kandori
The Journal of biological chemistry 294(10) 3432-3443 2019年3月 [査読有り]
The choanoflagellate Salpingoeca rosetta contains a chimeric rhodopsin protein composed of an N-terminal rhodopsin (Rh) domain and a C-terminal cyclic nucleotide phosphodiesterase (PDE) domain. The Rh-PDE enzyme light-dependently decreases the con...
UV radiation triggers the formation of an adjacent pyrimidine lesion in DNA, pyrimidine(6-4)pyrimidone photoproduct ((6-4)PP). These lesions are cytotoxic and interfere with cell replication and transcription, eventually inducing apoptosis, but th...
Journal of Structural and Functional Genomics 17(4) 69-81 2016年12月 [査読有り]
Life science research now heavily relies on all sorts of databases for genome sequences, transcription, protein three-dimensional (3D) structures, protein–protein interactions, phenotypes and so forth. The knowledge accumulated by all the omics re...
Daichi Yamada Hisham M. Dokainish Tatsuya Iwata Junpei Yamamoto Tomoko Ishikawa Takeshi Todo Shigenori Iwai Elizabeth D. Getzoff Akio Kitao Hideki Kandori
BIOCHEMISTRY 55(30) 4173-4183 2016年8月 [査読有り]
Ultraviolet (UV) light from the sun damages DNA by forming a cyclobutane pyrimidine dimer (CPD) and pyrimidine(6-4)pyrimidone photoproducts [(6-4) PP]. Photolyase (PHR) enzymes utilize near-UV/blue light for DNA repair, which is initiated by light...
Daichi Yamada Junpei Yamamoto Yu Zhang Tatsuya Iwata Kenichi Hitomi Elizabeth D. Getzoff Shigenori Iwai Hideki Kandori
BIOCHEMISTRY 55(4) 715-723 2016年2月 [査読有り]
Phetolyases (PHRs) repair the UV-induced photoproducts, cyclobutane pyrimidine dirtier (CPD) or pyrimidine-pyrimidone (6-4) photoproduct [(6-4) PP], restoring normal bases to, maintain genetic integrity. CPD and (6-4) PP are repaired by substrate-...
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理学研究科