Masahito Watari   Tatsuya Ikuta   Daichi Yamada   Wataru Shihoya   Kazuho Yoshida   Satoshi P Tsunoda   Osamu Nureki   Hideki Kandori   
The Journal of biological chemistry 294(10) 3432-3443 2019年3月 [査読有り]
The choanoflagellate Salpingoeca rosetta contains a chimeric rhodopsin protein composed of an N-terminal rhodopsin (Rh) domain and a C-terminal cyclic nucleotide phosphodiesterase (PDE) domain. The Rh-PDE enzyme light-dependently decreases the con...
UV radiation triggers the formation of an adjacent pyrimidine lesion in DNA, pyrimidine(6-4)pyrimidone photoproduct ((6-4)PP). These lesions are cytotoxic and interfere with cell replication and transcription, eventually inducing apoptosis, but th...
Journal of Structural and Functional Genomics 17(4) 69-81 2016年12月 [査読有り]
Life science research now heavily relies on all sorts of databases for genome sequences, transcription, protein three-dimensional (3D) structures, protein–protein interactions, phenotypes and so forth. The knowledge accumulated by all the omics re...
Daichi Yamada   Hisham M. Dokainish   Tatsuya Iwata   Junpei Yamamoto   Tomoko Ishikawa   Takeshi Todo   Shigenori Iwai   Elizabeth D. Getzoff   Akio Kitao   Hideki Kandori   
BIOCHEMISTRY 55(30) 4173-4183 2016年8月 [査読有り]
Ultraviolet (UV) light from the sun damages DNA by forming a cyclobutane pyrimidine dimer (CPD) and pyrimidine(6-4)pyrimidone photoproducts [(6-4) PP]. Photolyase (PHR) enzymes utilize near-UV/blue light for DNA repair, which is initiated by light...
Phetolyases (PHRs) repair the UV-induced photoproducts, cyclobutane pyrimidine dirtier (CPD) or pyrimidine-pyrimidone (6-4) photoproduct [(6-4) PP], restoring normal bases to, maintain genetic integrity. CPD and (6-4) PP are repaired by substrate-...
D. Yamada   H. M. Dokainish   T. Iwata   J. Yamamoto   T. Ishikawa   T. Todo   S. Iwai   E. D. Getzoff   K. Yura   A. Kitao   H. Kandori   
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 46 S82-S82 2017年7月