The Journal of biological chemistry 105277-105277 2023年9月
Cytochrome c oxidase (CcO) reduces O2 in the O2-reduction site by sequential four-electron donations through the low-potential metal sites (CuA and Fea). Redox-coupled X-ray crystal structural changes have been identified at five distinct sites in...
Antimicrobial resistance (AMR) is a global health problem. Despite the enormous efforts made in the last decade, threats from some species, including drug-resistant Neisseria gonorrhoeae, continue to rise and would become untreatable. Th...
Journal of Biological Chemistry 297(3) 100967-100967 2021年9月 [査読有り]
Mammalian cytochrome c oxidase (CcO) reduces O2 to water in a bimetallic site including Fea3 and CuB giving intermediate molecules, termed A-, P-, F-, O-, E-, and R-forms. From the P-form on, each reaction step is driven by single-electron donatio...
Biophysics and Physicobiology 18 186-195 2021年8月 [査読有り][招待有り]
Cytochrome c oxidase (CcO), a terminal oxidase in the respiratory chain, catalyzes the reduction of O2 to water coupled with the proton pump across the membrane. Mitochondrial CcO exists in monomeric and dimeric forms, and as a monomer as part of ...
BIN MOHAMAD JAMALI Muhamad Arif GOPALASINGAM Chai C. JOHNSON Rachel M. MUENCH Stephen P ANTONYUK Svetlana V. HASNAIN Samar S. TOSHA Takehiko MURAMOTO Kazumasa SHIRO Yoshitsugu
大学本部
理学研究科