Methods in Molecular Biology 1170 357-365 2014年 [査読有り]
Numerous cell cycle-regulating proteins are controlled by protein degradation. Recent work shows that ubiquitination-dependent proteolysis plays an important role in once-per-cell cycle control of DNA replication. Cdt1 is a licensing factor essent...
Methods in Molecular Biology 1170 367-382 2014年 [査読有り]
PCNA is a DNA clamp, acting on chromatin as a platform for various proteins involved in many aspects of DNA replication-linked processes. Most of these proteins have the PCNA-interaction protein motif (PIP box) that associates with PCNA. Recent wo...
JOURNAL OF BIOLOGICAL CHEMISTRY 287(48) 40256-40265 2012年11月 [査読有り]
Cells respond to DNA damage by activating alternate signaling pathways that induce proliferation arrest or apoptosis. The correct balance between these two pathways is important for maintaining genomic integrity and preventing unnecessary cell dea...
MOLECULAR AND CELLULAR BIOLOGY 32(12) 2279-2288 2012年6月 [査読有り]
Recent work identified the E3 ubiquitin ligase CRL4(Cdt2) as mediating the timely degradation of Cdt1 during DNA replication and following DNA damage. In both cases, proliferating cell nuclear antigen (PCNA) loaded on chromatin mediates the CRL4(C...
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理学研究科