Shumin Sun Fumiaki Hanzawa Daeun Kim Miki Umeki Syunsuke Nakajima Kumiko Sakai Saiko Ikeda Satoshi Mochizuki Hiroaki Oda
The Journal of biological chemistry 294(42) 15206-15217 2019年10月 [査読有り]
Metabolic syndrome has become a global health challenge and was recently reported to be positively correlated with increased sucrose consumption. Mechanistic analyses of excess sucrose-induced progression of metabolic syndrome have been focused ma...
Shumin Sun Fumiaki Hanzawa Miki Umeki Yasuko Matsuyama Naomichi Nishimura Saiko Ikeda Satoshi Mochizuki Hiroaki Oda
Chronobiology international 36(6) 826-837 2019年6月 [査読有り]
Excessive sucrose intake, known as fructose toxicity, leads to fatty liver, hyperlipidemia, and metabolic syndrome. Circadian disorders also contribute to metabolic syndrome. Here, we investigated the effect of excessive sucrose intake on circadia...
Shumin Sun Fumiaki Hanzawa Miki Umeki Saiko Ikeda Satoshi Mochizuki Hiroaki Oda
PloS one 13(8) e0201261 2018年 [査読有り]
The etiology of metabolic syndrome involves several complicated factors. One of the main factors contributing to metabolic syndrome has been proposed to be excessive intake of sucrose, which disturbs hepatic lipid metabolism, resulting in fatty li...
Journal of nutritional science and vitaminology 64(4) 243-250 2018年 [査読有り]
Previous studies have shown that α-tocopherol intake lowers phylloquinone (PK) concentration in some extrahepatic tissues in rats. The study's aim was to clarify the effect of α-tocopherol intake on vitamin K concentration in bone, as well as the ...
Hatsumi Shimizu* Fumiaki Hanzawa* Daeun Kim* Shumin Sun Thomas Laurent Miki Umeki Saiko Ikeda Satoshi Mochizuki Hiroaki Oda (equal contribution)
PloS one 13(10) e0206669 2018年 [査読有り]
The circadian clock is closely related to human health, such as metabolic syndrome and cardiovascular disease. Our previous study revealed that irregular feeding induced abnormal lipid metabolism with disruption of the hepatic circadian clock. We ...
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