今高寛晃

研究者氏名	今高寛晃
	イマタカヒロアキ
URL	http://www.eng.u-hyogo.ac.jp/group/group37/
所属	兵庫県立大学
部署	工学研究科
職名	教授
学位	農学博士(東京大学)
科研費研究者番号	50201942
J-Global ID	201801002037126056

プロフィール

１．学歴
１９７９年三重県立上野高等学校卒業
１９７９年東京大学理科２類入学
１９８３年東京大学農学部畜産獣医学科卒業
１９８5年獣医師免許取得
１９８８年東京大学大学院博士課程修了
２．職歴
１９８８年東北大学理学部ポスドク
１９９０年京都大学ウイルス研究所ポスドク
１９９４年 McGill大学医学部研究員
２００２年理化学研究所研究員
２００８年兵庫県立大学大学院工学研究科教授

研究キーワード

人工細胞 ,再構成 ,翻訳 ,タンパク質合成 ,合成生物学

研究分野

ライフサイエンス / システムゲノム科学 / 合成生物学

論文

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Identification of the T-complex protein as a binding partner for newly synthesized cytoplasmic dynein intermediate chain 2

Aysun Oezdemir Kodai Machida Hiroaki Imataka Andrew D. Catling

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 469(1) 126-131 2016年1月 [査読有り]

Cytoplasmic dynein is a macromolecular motor complex with diverse function's in eukaryotic cells. Dynein plays essential roles in intracellular transport of organelles and mitosis, mediated in part by interactions between the dynein intermediate c...

Production methods for viral particles

Kodai Machida Hiroaki Imataka

BIOTECHNOLOGY LETTERS 37(4) 753-760 2015年4月 [査読有り]

Viral particles and virus-like particles (VLPs) or capsids are becoming important vehicles and templates in bio-imaging, drug delivery and materials sciences. Viral particles are prepared by infecting the host organism but VLPs are obtained from c...

A Translation System Reconstituted with Human Factors Proves That Processing of Encephalomyocarditis Virus Proteins 2A and 2B Occurs in the Elongation Phase of Translation without Eukaryotic Release Factors

Kodai Machida Satoshi Mikami Mamiko Masutani Kurumi Mishima Tominari Kobayashi Hiroaki Imataka

JOURNAL OF BIOLOGICAL CHEMISTRY 289(46) 31960-31971 2014年11月 [査読有り]

Background: The mechanism by which the encephalomyocarditis virus protein 2A-2B is processed into 2A and 2B is unknown. Results: A translation system reconstituted with defined human factors recapitulates 2A-2B processing. Conclusion: 2A-2B proces...

MicroRNAs Trigger Dissociation of eIF4AI and eIF4AII from Target mRNAs in Humans

Akira Fukao Yuichiro Mishima Naoki Takizawa Shigenori Oka Hiroaki Imataka Jerry Pelletier Nahum Sonenberg Christian Thoma Toshinobu Fujiwara

MOLECULAR CELL 56(1) 79-89 2014年10月 [査読有り]

In animals, key functions of microRNA-induced silencing complex (miRISC) are translational repression and deadenylation followed by mRNA decay. While miRISC represses translation initiation, it is poorly understood how miRISC exerts this function....

Human cell extract-derived cell-free systems for virus synthesis

Tominari Kobayashi Kodai Machida Hiroaki Imataka

Methods in Molecular Biology 1118 149-156 2014年 [査読有り]

Cell-free synthesis of an infectious virus is an ideal tool for elucidating the mechanism of viral replication and for development of antiviral drugs. In this chapter, the synthesis of Encephalomyocarditis virus (EMCV) from RNA and DNA in a HeLa c...