今高寛晃

研究者氏名	今高寛晃
	イマタカヒロアキ
URL	http://www.eng.u-hyogo.ac.jp/group/group37/
所属	兵庫県立大学
部署	工学研究科
職名	教授
学位	農学博士(東京大学)
科研費研究者番号	50201942
J-Global ID	201801002037126056

プロフィール

１．学歴
１９７９年三重県立上野高等学校卒業
１９７９年東京大学理科２類入学
１９８３年東京大学農学部畜産獣医学科卒業
１９８5年獣医師免許取得
１９８８年東京大学大学院博士課程修了
２．職歴
１９８８年東北大学理学部ポスドク
１９９０年京都大学ウイルス研究所ポスドク
１９９４年 McGill大学医学部研究員
２００２年理化学研究所研究員
２００８年兵庫県立大学大学院工学研究科教授

研究キーワード

人工細胞 ,再構成 ,翻訳 ,タンパク質合成 ,合成生物学

研究分野

ライフサイエンス / システムゲノム科学 / 合成生物学

論文

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Purification and visualization of encephalomyocarditisvirus synthesized by an in vitro protein expression system derived from mammalian cell extract

Tominari Kobayashi Jun Yukigai Kosaku Ueda Kodai Machida Mamiko Masutani Yuri Nishino Atsuo Miyazawa Hiroaki Imataka

BIOTECHNOLOGY LETTERS 35(3) 309-314 2013年3月 [査読有り]

Virus particles are promising vehicles and templates for vaccination, drug delivery and material sciences. Although infectious picornaviruses can be synthesized from genomic or synthetic RNA by cell-free protein expression systems derived from mam...

Reconstitution of eukaryotic translation initiation factor 3 by co-expression of the subunits in a human cell-derived in vitro protein synthesis system

Mamiko Masutani Kodai Machida Tominari Kobayashi Shigeyuki Yokoyama Hiroaki Imataka

PROTEIN EXPRESSION AND PURIFICATION 87(1) 5-10 2013年1月 [査読有り]

Many biologically important factors are composed of multiple subunits. To study the structure and function of the protein complexes and the role of each subunit, a rapid and efficient method to prepare recombinant protein complexes is needed. In t...

Single-molecule imaging with a tagged ribosome to explore trans-translation

Hiroaki Imataka

JOURNAL OF BIOCHEMISTRY 152(4) 293-295 2012年10月 [査読有り]

Single-molecule imaging is a powerful technique to visualize molecular interactions and movements. Translation is one of the most interesting targets for researchers with the molecular-imaging skills, since mRNA, tRNA and translation factors inter...

Translational Homeostasis via the mRNA Cap-Binding Protein, elF4E

Akiko Yanagiya Eigo Suyama Hironori Adachi Yuri V. Svitkin Pedro Aza-Blanc Hiroaki Imataka Satoshi Mikami Yvan Martineau Ze'ev A. Ronai Nahum Sonenberg

MOLECULAR CELL 46(6) 847-858 2012年6月 [査読有り]

Translational control of gene expression plays a key role in many biological processes. Consequently, the activity of the translation apparatus is under tight homeostatic control. elF4E, the mRNA 5' cap-binding protein, facilitates cap-dependent t...

Functional and direct interaction between the RNA binding protein HuD and active Akt1

Toshinobu Fujiwara Akira Fukao Yumi Sasano Hidenori Matsuzaki Ushio Kikkawa Hiroaki Imataka Kunio Inoue Shogo Endo Nahum Sonenberg Christian Thoma Hiroshi Sakamoto

NUCLEIC ACIDS RESEARCH 40(5) 1944-1953 2012年3月 [査読有り]

The RNA binding protein HuD plays essential roles in neuronal development and plasticity. We have previously shown that HuD stimulates translation. Key for this enhancer function is the linker region and the poly(A) binding domain of HuD that are ...