石坂朱里

研究者氏名	石坂朱里

URL
所属	兵庫県立大学
部署	環境人間学部
職名	助教
学位	栄養学
J-Global ID	202001014532287720

論文

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Mitochondrial dysfunction leads to deconjugation of quercetin glucuronides in inflammatory macrophages.

Akari Ishisaka Kyuichi Kawabata Satomi Miki Yuko Shiba Shoko Minekawa Tomomi Nishikawa Rie Mukai Junji Terao Yoshichika Kawai

PloS one 8(11) e80843 2013年

Dietary flavonoids, such as quercetin, have long been recognized to protect blood vessels from atherogenic inflammation by yet unknown mechanisms. We have previously discovered the specific localization of quercetin-3-O-glucuronide (Q3GA), a phase...

Effect of quercetin and its glucuronide metabolite upon 6-hydroxydopamine-induced oxidative damage in Neuro-2a cells.

Rie Mukai Kyuichi Kawabata Seiko Otsuka Akari Ishisaka Yoshichika Kawai Zai-Si Ji Hiroshi Tsuboi Junji Terao

Free radical research 46(8) 1019-28 2012年8月

Quercetin is ubiquitously distributed in plant foods. This antioxidative polyphenol is mostly converted to conjugated metabolites in the body. Parkinson disease (PD) has been suggested to be related to oxidative stress derived from abnormal dopami...

Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats.

Akari Ishisaka Satomi Ichikawa Hiroyuki Sakakibara Mariusz K Piskula Toshiyuki Nakamura Yoji Kato Mikiko Ito Ken-ichi Miyamoto Akira Tsuji Yoshichika Kawai Junji Terao

Free radical biology & medicine 51(7) 1329-36 2011年10月

Quercetin is widely distributed in vegetables and herbs and has been suggested to act as a neuroprotective agent. Here, we demonstrate that quercetin can accumulate enough to exert biological activity in rat brain tissues. Homogenates of perfused ...

Effect of quercetin and glucuronide metabolites on the monoamine oxidase-A reaction in mouse brain mitochondria.

Saki Yoshino Aya Hara Hiroyuki Sakakibara Kyuichi Kawabata Akira Tokumura Akari Ishisaka Yoshichika Kawai Junji Terao

Nutrition (Burbank, Los Angeles County, Calif.) 27(7-8) 847-52 2011年

OBJECTIVE: Quercetin is a flavonoid found in plant foods and herbal medicines. It possesses antidepressant-like effects in forced swimming test-loaded rodents. We wanted to clarify the mechanism of action of dietary quercetin for exerting antidepr...

Different profiles of quercetin metabolites in rat plasma: comparison of two administration methods.

Yoshichika Kawai Satomi Saito Tomomi Nishikawa Akari Ishisaka Kaeko Murota Junji Terao

Bioscience, biotechnology, and biochemistry 73(3) 517-23 2009年3月

The bioavailability of polyphenols in human and rodents has been discussed regarding their biological activity. We found different metabolite profiles of quercetin in rat plasma between two administration procedures. A single intragastric administ...