JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 25(4) 761-772 2014年4月 [査読有り]
Marked hypophosphatemia is common after major hepatic resection, but the pathophysiologic mechanism remains unknown. We used a partial hepatectomy (PH) rat model to investigate the molecular basis of hypophosphatemia. PH rats exhibited hypophospha...
JOURNAL OF RENAL NUTRITION 23(2) E11-E20 2013年3月 [査読有り]
Background: Both organic and inorganic phosphorus (Pi) are present in regularly consumed foods, such as meats, eggs, and dairy products. Pi is often included in foods as an additive (as hidden phosphorus). The intestinal peptide transporter PepT1 ...
Journal of Medical Investigation 60(1-2) 27-34 2013年 [査読有り]
Type IIa sodium-dependent phosphate transporter (NaPi-IIa) is responsible for renal phosphate reabsorption and maintenance of systemic phosphate homeostasis in mammals. Macromolecular complex formation of NaPi-IIa with sodium-proton exchanger rela...
Sakiko Haito-Sugino   Mikiko Ito   Akiko Ohi   Yuji Shiozaki   Natsumi Kangawa   Takashi Nishiyama   Fumito Aranami   Shohei Sasaki   Ayaka Mori   Shinsuke Kido   Sawako Tatsumi   Hiroko Segawa   Ken-ichi Miyamoto   
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 302(9) C1316-C1330 2012年5月 [査読有り]
Haito-Sugino S, Ito M, Ohi A, Shiozaki Y, Kangawa N, Nishiyama T, Aranami F, Sasaki S, Mori A, Kido S, Tatsumi S, Segawa H, Miyamoto K. Processing and stability of type IIc sodium-dependent phosphate cotransporter mutations in patients with heredi...
Journal of Medical Investigation 59(1-2) 116-126 2012年2月 [査読有り]
Mutations in the SLC34A3 gene, a sodium-dependent inorganic phosphate (Pi) cotransporter, also referred to as NaPi IIc, causes hereditary hypophosphatemic rickets with hypercalciuria (HHRH), an autosomal recessive disorder. In human and rodent, Na...