MOLECULAR BIOLOGY OF THE CELL 23(8) 1593-1604 2012年4月 [査読有り]
The Rnd proteins Rnd1, Rnd2, and Rnd3/RhoE are well known as key regulators of the actin cytoskeleton in various cell types, but they comprise a distinct subgroup of the Rho family in that they are GTP bound and constitutively active. Functional d...
Izumi Oinuma   Yuri Ito   Hironori Katoh   Manabu Negishi   
JOURNAL OF BIOLOGICAL CHEMISTRY 285(36) 28200-28209 2010年9月 [査読有り]
Plexins are receptors for axonal guidance molecules semaphorins. We recently reported that the semaphorin 4D (Sema4D) receptor, Plexin-B1, suppresses PI3K signaling through the R-Ras GTPase-activating protein (GAP) activity, inducing growth cone c...
Plexins are receptors for axonal guidance molecules known as semaphorins. We recently reported that the semaphorin 4D (Sema4D) receptor, Plexin-B1, induces axonal growth cone collapse by functioning as an R-Ras GTPase activating protein (GAP). Her...
JOURNAL OF BIOLOGICAL CHEMISTRY 284(11) 6743-6751 2009年3月 [査読有り]
Plexins, comprising Plexin-A, -B, -C, and -D subfamilies, are receptors for semaphorins governing cell adhesion, migration, and axon guidance. Among plexin subfamilies, Plexin-A1 and Plexin-B1 have been shown to function as an R-Ras GAP, inducing ...
Oscar Gee-Wan Wong, Tharani Nitkunan, Izumi Oinuma, Chun Zhou, Veronique Blanc, Richard S D Brown, Simon R J Bott, Joseph Nariculam, Gary Box, Phillipa Munson, Jason Constantinou, Mark R Feneley, Helmut Klocker, Suzanne A Eccles, Manabu Negishi, Alex Freeman, John R Masters, Magali Williamson