Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals 437-445 2016年9月 [査読有り]
The sodium-dependent phosphate cotransporter (NaPi) family plays a critical role in Pi homeostasis in mammals via several mechanisms, including renal tubular reabsorption, intestinal absorption, and exchange with intracellular or bone storage. The...
JOURNAL OF BONE AND MINERAL METABOLISM 34(1) 1-10 2016年1月 [査読有り]
In this review, we focus on the interconnection of inorganic phosphate (Pi) homeostasis in the network of the bone-kidney, parathyroid-kidney, intestine-kidney, and liver-kidney axes. Such a network of organ communication is important for body Pi ...
Yuji Shiozaki   Hiroko Segawa   Saori Ohnishi   Akiko Ohi   Mikiko Ito   Ichiro Kaneko   Shinsuke Kido   Sawako Tatsumi   Ken-ichi Miyamoto   
Journal of Medical Investigation 62(3) 209-218 2015年9月 [査読有り]
NaPi-IIc/SLC34A3 is a sodium-dependent inorganic phosphate (Pi) transporter in the renal proximal tubules and its mutations cause hereditary hypophosphatemic rickets with hypercalciuria (HHRH). In the present study, we created a specific antibody ...
Ichiro Kaneko   Marya S. Sabir   Christopher M. Dussik   G. Kerr Whitfield   Amitis Karrys   Jui-Cheng Hsieh   Mark R. Haussler   Mark B. Meyer   J. Wesley Pike   Peter W. Jurutka   
FASEB JOURNAL 29(9) 4023-4035 2015年9月 [査読有り]
To investigate vitamin D-related control of brain-expressed genes, candidate vitamin D responsive elements (VDREs) at -7/-10 kb in human tryptophan hydroxylase (TPH) 2 were probed. Both VDREs bound the vitamin D receptor (VDR)-retinoid X receptor ...
Ichiro Kaneko   Rimpi K. Saini   Kristin P. Griffin   G. Kerr Whitfield   Mark R. Haussler   Peter W. Jurutka   
JOURNAL OF ENDOCRINOLOGY 226(3) 155-166 2015年9月 [査読有り]
In a closed endocrine loop, 1,25-dihydroxyvitamin D-3 (1,25D) induces the expression of fibroblast growth factor 23 (FGF23) in bone, with the phosphaturic peptide in turn acting at kidney to feedback repress CYP27B1 and induce CYP24A1 to limit the...