Kodai Machida Kuru Kanzawa Tomoaki Shigeta Yuki Yamamoto Kanta Tsumoto Hiroaki Imataka
ACS synthetic biology 7(2) 377-383 2018年2月 [査読有り]
One of the aims of synthetic biology is bottom-up construction of reconstituted human cells for medical uses. To that end, we generated giant unilamellar vesicles (GUVs) that contained a HeLa cell extract, which comprises a cell-free protein synth...
Eri Uemura Tatsuya Niwa Shintaro Minami Kazuhiro Takemoto Satoshi Fukuchi Kodai Machida Hiroaki Imataka Takuya Ueda Motonori Ota Hideki Taguchi
Scientific reports 8(1) 678-678 2018年1月 [査読有り]
A subset of the proteome is prone to aggregate formation, which is prevented by chaperones in the cell. To investigate whether the basic principle underlying the aggregation process is common in prokaryotes and eukaryotes, we conducted a large-sca...
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY 83(2) 252-258 2017年8月 [査読有り]
A high proton-conducting P2O5-SiO2 nanoporous glass rod was prepared via sol-gel technique, and its tip was sharpened by a meniscus-etching method. The glass rod shows proton conductivity of 1 x 10(-3) at room temperature after absorption of water...
Protein misfolding and aggregation is one of the major causes of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and Huntington's disease. So far protein aggregation related to these diseases has been studied using ani...
Journal of biochemistry 159(2) 247-60 2016年2月 [査読有り]
Cu, Zn-superoxide dismutase (SOD1), an enzyme implicated in the progression of familial amyotrophic lateral sclerosis (fALS), forms amyloid fibrils under certain experimental conditions. As part of our efforts to understand ALS pathogenesis, in th...
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