To isolate novel genes regulating neural induction, we used a DNA microarray approach. As neural induction is thought to occur by means of the inhibition of bone morphogenetic protein (BMP) signaling, BMP signaling was inhibited in ectodermal cell...
Bone morphogenetic proteins (BMPs), a subgroup of the transforming growth factor-beta (TGF-beta) superfamily, were originally isolated from bone on the basis of their ability to induce ectopic bone development. Although BMPs are involved in a wide...
Shin Y   Kitayama A   Koide T   Peiffer D.A   Mochii M   Liao A   Ueno N   Cho K.W.Y   
H Orii   M Mochii   K Watanabe   
DEVELOPMENT GENES AND EVOLUTION 213(3) 138-141 2003年4月 [査読有り]
A simple method was developed for RNA interference (RNAi) in the planarian Dugesia japonica. The DjIFb (Dugesia japonica intermediate filament b) gene was used to evaluate the effect of RNAi because both the cDNA and an antiserum against the gene ...
Amputation of the larval tail of Xenopus injures the notochord, spinal cord, muscle masses, mesenchyme, and epidermis, induces the growth and differentiation of cells in those tissues, and results in tail regeneration. A dorsal incision in the lar...
DEVELOPMENT GROWTH & DIFFERENTIATION 50(3) 169-180 2008年4月
We examined several candidate posterior/mesodermal inducing molecules using permanent blastula-type embryos (PBEs) as an assay system. Candidate molecules were injected individually or in combination with the organizer factor chordin mRNA. Injecti...
DEVELOPMENT GROWTH & DIFFERENTIATION 50(2) 109-120 2008年2月
Tail regeneration in urodeles is dependent on the spinal cord (SC), but it is believed that anuran larvae regenerate normal tails without the SC. To evaluate the precise role of the SC in anuran tail regeneration, we developed a simple operation m...
DEVELOPMENT GROWTH & DIFFERENTIATION 49(2) 155-161 2007年2月
The tail of the Xenopus tadpole contains major axial structures, including a spinal cord, notochord and myotomes, and regenerates within 2 weeks following amputation. The tail regeneration in Xenopus can provide insights into the molecular basis o...
MECHANISMS OF DEVELOPMENT 123(10) 746-760 2006年10月
We succeeded in visualization of the primordial germ cells (PGCs) in a living Xenopus embryo. The mRNA of the reporter Venus protein, fused to the 3' untranslated region (UTR) of DEADSouth, which is a component of the germ plasm in Xenopus eggs, w...
所属学協会
日本動物学会
国際発生生物学会(International Society of Developmental Biologysts)