Photosystem II (PSII) catalyses the oxidation of water through a four-step cycle of Si states (i = 0–4) at the Mn4CaO5 cluster1–3, during which an extra oxygen (O6) is incorporated at the S<sub...
Alexander M. Wolff   Eriko Nango   Iris D. Young   Aaron S. Brewster   Minoru Kubo   Takashi Nomura   Michihiro Sugahara   Shigeki Owada   Benjamin A. Barad   Kazutaka Ito   Asmit Bhowmick   Sergio Carbajo   Tomoya Hino   James M. Holton   Dohyun Im   Lee J. O’Riordan   Tomoyuki Tanaka   Rie Tanaka   Raymond G. Sierra   Fumiaki Yumoto   Kensuke Tono   So Iwata   Nicholas K. Sauter   James S. Fraser   Michael C. Thompson   
Nature Chemistry 15(11) 1549-1558 2023年9月 [査読有り]
Abstract
Understanding and controlling protein motion at atomic resolution is a hallmark challenge for structural biologists and protein engineers because conformational dynamics are essential for complex functions such as enzyme catalysis and al...
Ionotropic glutamate receptors are ligand-gated ion channels involved in neurotransmission. In 1998, a crystal structure was first solved for the soluble mini-receptor that only included the S1S2 ligand-binding domain of the rat GluR2 subunit. Sin...