西谷秀男

研究者氏名	西谷秀男

所属	兵庫県立大学
部署	大学院理学研究科　生体情報学II
職名	教授
学位	理学博士(九州大学)
J-Global ID	201801017657794196

研究分野

ライフサイエンス / 分子生物学 /

経歴

12 >

2020年4月

現在

兵庫県立大学大学院理学研究科

2007年4月

現在

兵庫県立大学大学院生命理学研究科教授

1997年

2007年3月

九州大学大学院医学系研究科助教

1993年

1997年

英国ガン研究基金研究所(ICRF) Cell Cycle lab 博士研究員

1991年

1992年

日本学術振興会特別研究員

学歴

九州大学大学院医学系研究科

九州大学大学院理学研究科

京都大学理学部

論文

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Mismatch repair proteins recruited to ultraviolet light-damaged sites lead to degradation of licensing factor Cdt1 in the G1 phase

Miyuki Tanaka Michiyo Takahara Kohei Nukina Akiyo Hayashi Wataru Sakai Kaoru Sugasawa Yasushi Shiomi Hideo Nishitani

CELL CYCLE 16(7) 673-684 2017年 [査読有り]

Cdt1 is rapidly degraded by CRL4(Cdt2) E3 ubiquitin ligase after UV (UV) irradiation. Previous reports revealed that the nucleotide excision repair (NER) pathway is responsible for the rapid Cdt1-proteolysis. Here, we show that mismatch repair (MM...

Mitotic UV Irradiation Induces a DNA Replication-Licensing Defect that Potentiates G1 Arrest Response

Masayuki Morino Kohei Nukina Hiroki Sakaguchi Takeshi Maeda Michiyo Takahara Yasushi Shiomi Hideo Nishitani

PLOS ONE 10(3) 2015年3月 [査読有り]

Cdt1 begins to accumulate in M phase and has a key role in establishing replication licensing at the end of mitosis or in early G1 phase. Treatments that damage the DNA of cells, such as UV irradiation, induce Cdt1 degradation through PCNA-depende...

RanBP9 Modulates AICD Localization and Transcriptional Activity via Direct Interaction with Tip60

Sara C. Dominguesa Uwe Konietzko Ana Gabriela Henriques Sandra Rebelo Margarida Fardilha Hideo Nishitani Roger M. Nitsch Edgar F. da Cruz e Silva Odete A. B. da Cruz e Silva

JOURNAL OF ALZHEIMERS DISEASE 42(4) 1415-1433 2014年 [査読有り]

Proteolytic processing of the amyloid-beta protein precursor (A beta PP) occurs via alternative pathways, culminating with the production of the A beta PP intracellular domain (AICD). AICD can translocate to the nucleus and regulate transcription,...

PCNA-dependent ubiquitination of Cdt1 and p21 in mammalian cells

Akiyo Hayashi Naohiro Suenaga Yasushi Shiomi Hideo Nishitani

Methods in Molecular Biology 1170 367-382 2014年 [査読有り]

PCNA is a DNA clamp, acting on chromatin as a platform for various proteins involved in many aspects of DNA replication-linked processes. Most of these proteins have the PCNA-interaction protein motif (PIP box) that associates with PCNA. Recent wo...

Imaging analysis to determine chromatin binding of the licensing factor MCM2-7 in mammalian cells

Masayuki Morino Miyuki Tanaka Yasushi Shiomi Hideo Nishitani

Methods in Molecular Biology 1170 529-537 2014年 [査読有り]

S-CDK and DDK protein kinases initiate DNA replication at replication origins. Prior to the activation of these kinases, origins must become competent for replication by loading MCM2-7 DNA helicase on chromatin. This process is known as replicatio...