西谷秀男

研究者氏名	西谷秀男

所属	兵庫県立大学
部署	大学院理学研究科　生体情報学II
職名	教授
学位	理学博士(九州大学)
J-Global ID	201801017657794196

研究分野

ライフサイエンス / 分子生物学 /

経歴

12 >

2020年4月

現在

兵庫県立大学大学院理学研究科

2007年4月

現在

兵庫県立大学大学院生命理学研究科教授

1997年

2007年3月

九州大学大学院医学系研究科助教

1993年

1997年

英国ガン研究基金研究所(ICRF) Cell Cycle lab 博士研究員

1991年

1992年

日本学術振興会特別研究員

学歴

九州大学大学院医学系研究科

九州大学大学院理学研究科

京都大学理学部

論文

<4 567 8 >

Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, are important for CRL4Cdt2-mediated proteolysis

Masato Michishita Aya Morimoto Takashi Ishii Hirofumi Komori Yasushi Shiomi Yoshiki Higuchi Hideo Nishitani

GENES TO CELLS 16(1) 12-22 2011年1月 [査読有り]

PCNA links Cdt1 and p21 for proteolysis by Cul4-DDB1-Cdt2 (CRL4Cdt2) in the S phase and after DNA damage in mammalian cells. However, other PCNA-interacting proteins, such as ligase I, are not targets of CRL4Cdt2. In this study, we created chimera...

Proliferating Cell Nuclear Antigen-dependent Rapid Recruitment of Cdt1 and CRL4(Cdt2) at DNA-damaged Sites after UV Irradiation in HeLa Cells

Takashi Ishii Yasushi Shiomi Toshihiro Takami Yusuke Murakami Naho Ohnishi Hideo Nishitani

JOURNAL OF BIOLOGICAL CHEMISTRY 285(53) 41993-42000 2010年12月 [査読有り]

The licensing factor Cdt1 is degraded by CRL4(Cdt2) ubiquitin ligase dependent on proliferating cell nuclear antigen (PCNA) during S phase and when DNA damage is induced in G(1) phase. Association of both Cdt2 and PCNA with chromatin was observed ...

START-GAP2/DLC2 is localized in focal adhesions via its N-terminal region

Katsuhisa Kawai Jun-ichi Seike Takuya Lino Minoru Kiyota Yui Iwamae Hideo Nishitani Hitoshi Yagisawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 380(4) 736-741 2009年3月 [査読有り]

START-GAP2, also termed as DLC2, is a START domain-containing RhoGAP and a negative regulator of RhoA and Cdc42. Although it was reported as a tumor suppresser gene product, the molecular basis for function of START-GAP2 remains to be clarified. H...

CDK Inhibitor p21 Is Degraded by a Proliferating Cell Nuclear Antigen-coupled Cul4-DDB1(Cdt2) Pathway during S Phase and after UV Irradiation

Hideo Nishitani Yasushi Shiomi Hiroka Iida Masato Michishita Toshihiro Takami Toshiki Tsurimoto

JOURNAL OF BIOLOGICAL CHEMISTRY 283(43) 29045-29052 2008年10月 [査読有り]

Previous reports showed that chromatin-associated PCNA couples DNA replication with Cul4-DDB1(Cdt2)-dependent proteolysis of the licensing factor Cdt1. The CDK inhibitor p21, another PCNA-binding protein, is also degraded both in S phase and after...

Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity

Motoaki Ohtsubo Shin'ichiro Yasunaga Yoshinori Ohno Miyuki Tsumura Satoshi Okada Nobutsune Ishikawa Kenichiro Shirao Akira Kikuchi Hideo Nishitani Masao Kobayashi Yoshihiro Takihara

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105(30) 10396-10401 2008年7月 [査読有り]

Polycomb-group (PcG) genes encode multimeric nuclear protein complexes, PcG complex 1 and 2. PcG complex 2 was proved to induce transcription repression and to further methylate histone H3 at lysine-27 (H3K27). Subsequently PcG complex 1 is recrui...