Georgia Xouri Anthony Squire Maria Dimaki Bart Geverts Peter J. Verveer Stavros Taraviras Hideo Nishitani Adriaan B. Houtsmuller Philippe I. H. Bastiaens Zoi Lygerou
EMBO JOURNAL 26(5) 1303-1314 2007年3月 [査読有り]
To maintain genome integrity, eukaryotic cells initiate DNA replication once per cell cycle after assembling pre-replicative complexes (preRCs) on chromatin at the end of mitosis and during G1. In S phase, preRCs are dis assembled, precluding init...
MOLECULAR REPRODUCTION AND DEVELOPMENT 74(2) 223-232 2007年2月 [査読有り]
lba1 is a 17-kDa EF-hand protein highly expressed in the cytoplasm of elongating spermatids in testis. Using Iba1 as a bait, we performed yeast Two-hybrid screening and isolated a heat-shock protein Hsp40, DjB1, from cDNA library of mouse testis. ...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 353(2) 330-336 2007年2月 [査読有り]
RanGTPase is involved in many cellular processes. It functions in nuclear-cytosolic transport and centrosome formation. Ran also localizes to chromatin as RCC1 does, its guanine nucleotide exchange factor, but Ran's function on chromatin is not kn...
H Nishijima J Nakayama T Yoshioka A Kusano H Nishitani K Shibahara T Nishimoto
MOLECULAR BIOLOGY OF THE CELL 17(6) 2524-2536 2006年6月 [査読有り]
Although the Ran GTPase-activating protein RanGAP mainly functions in the cytoplasm, several lines of evidence indicate a nuclear function of RanGAP. We found that Schizosaccharomyces pombe RanGAP, SpRna1, bound the core of histone H3 (H3) and enh...
H Nishitani N Sugimoto Roukos, V Y Nakanishi M Saijo C Obuse T Tsurimoto KI Nakayama K Nakayama M Fujita Z Lygerou T Nishimoto
EMBO JOURNAL 25(5) 1126-1136 2006年3月 [査読有り]
Replication licensing is carefully regulated to restrict replication to once in a cell cycle. In higher eukaryotes, regulation of the licensing factor Cdt1 by proteolysis and Geminin is essential to prevent re-replication. We show here that the N-...
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理学研究科