E Hirose M Mukai A Shimada H Nishitani Y Shibata T Nishimoto
GENES TO CELLS 11(1) 29-46 2006年1月 [査読有り]
RCC1, a conserved chromosomal protein with a seven-bladed propeller is a GDP/GTP nucleotide exchange factor for RanGTPase that mediates various cellular events. We isolated 16 temperature-sensitive (ts) mutants of S. pombeRCC1-homolog, pim1(+), by...
Bravou, V H Nishitani SY Song S Taraviras J Varakis
INTERNATIONAL JOURNAL OF ONCOLOGY 27(6) 1511-1518 2005年12月 [査読有り]
Licensing of chromatin for replication is an evolutionarily conserved step in the control of cell division and genomic integrity. Proteins that participate in licensing have been recently documented to denote the proliferative state of cells and t...
A Kusano T Yoshioka H Nishijima H Nishitani T Nishimoto
MOLECULAR BIOLOGY OF THE CELL 15(11) 4960-4970 2004年11月 [査読有り]
We isolated 11 independent temperature-sensitive (ts) mutants of Schizosaccharomyces pombe RanGAP, SpRna1 that have several amino acid changes in the conserved domains of RanGAP. Resulting Sprna1(ts) showed a strong defect in mitotic chromosome se...
P Karakaidos S Taraviras LV Vassiliou P Zacharatos NG Kastrinakis D Kougiou M Kouloukoussa H Nishitani AG Papavassiliou Z Lygerou VG Gorgoulis
AMERICAN JOURNAL OF PATHOLOGY 165(4) 1351-1365 2004年10月 [査読有り]
Replication licensing ensures once per cell cycle replication and is essential for genome stability. Overexpression of two key licensing factors, Cdc6 and Cdt1, leads to overreplication and chromosomal instability (CIN) in lower eukaryotes and rec...
FRONTIERS IN BIOSCIENCE 9 2115-2132 2004年9月 [査読有り]
The DNA replication licensing system ensures that chromosomal DNA is replicated precisely once before cell division occurs. A DNA helicase must be loaded on origin DNA for replication to initiate. Considerable evidence suggests that the MCM comple...
大学本部
理学研究科