tRNAの量的調節機構の解析
,核-細胞質間物質輸送 tRNAの細胞内動態 tRNAのスプライシング RNAの品質管理
,nuclear-cytoplasmic transport intracellular dynamics of tRNA tRNA splicing quality control of RNA
Nucleic Acids Research 47(11) 5936-5949 2019年6月 [査読有り]
In eukaryotes and archaea, tRNA genes frequently contain introns, which are removed during maturation. However, biological roles of tRNA introns remain elusive. Here, we constructed a complete set of Saccharomyces cerevisiae strains in which the i...
tRNAs, a class of non-coding RNAs essential for translation, are unique among cytosolic RNA species in that they shuttle between the nucleus and cytoplasm during their life. Although their export from the nucleus has been studied in detail, limite...
JOURNAL OF BIOLOGICAL CHEMISTRY 290(26) 16021-16030 2015年6月 [査読有り]
Background: The yeast tRNA splicing endonuclease (Sen) complex is located on the mitochondrial outer membrane and splices precursor tRNAs. Results: The Sen complex cleaves the mitochondria-localized CBP1 mRNA in vivo and in vitro. Conclusion: Mito...
tRNAs are unique among various RNAs in that they shuttle between the nucleus and the cytoplasm, and their localization is regulated by nutrient conditions. Although nuclear export of tRNAs has been well documented, the import machinery is poorly u...