tRNAの量的調節機構の解析
,核-細胞質間物質輸送 tRNAの細胞内動態 tRNAのスプライシング RNAの品質管理
,nuclear-cytoplasmic transport intracellular dynamics of tRNA tRNA splicing quality control of RNA
The Saccharomyces cerevisiae uses a highly glycolytic metabolism, if glucose is available, through appropriately suppressing mitochondrial functions except for some of them such as Fe/S cluster biogenesis. Puf3p, a Pumillio family protein, plays a...
Bioscience, biotechnology, and biochemistry 86(10) 1398-1404 2022年8月 [査読有り]
Saccharomyces cerevisiae has six synonymous tRNATrpCCA genes encoding the identical sequence, including their intronic region. They are supposed to express tRNATrpCCA in the same quality and quantity. Here, we generated single to quintuple deletio...
Yeasts generally grow with a highly glycolytic metabolism and restrain mitochondrial biogenesis except for some Fe/S proteins. Respiratory mitochondrial functions and biosynthesis pathways are well studied, however how cells coordinate b...
Akihisa Nagai   Kohei Mori   Yuma Shiomi   Tohru Yoshihisa   
RNA (New York, N.Y.) 27(5) 628-640 2021年3月 [査読有り]
To maintain optimal proteome, both codon choice of each mRNA and supply of aminoacyl-tRNAs are two principal factors in translation. Recent reports have revealed that the amounts of tRNAs in cells are more dynamic than we had expected. High-throug...
<title>Abstract</title>eIF2α phosphorylation-mediated translational regulation is crucial for global translation repression by various stresses, including the unfolded protein response (UPR). However, translational control during UPR has not been ...