Naoko Suga Akira Murakami Yoshimasa Nakamura Akari Ishisaka Noritoshi Kitamoto Mikiko Ito Yoji Kato
FREE RADICAL RESEARCH 51(5) 545-553 2017年 [査読有り]
Serotonin (5-hydroxytryptamine) is a putative substrate for myeloperoxidase, which may convert it into the reactive quinone tryptamine-4,5-dione (TD). In this study, we found that the viability of human SH-SY5Y neuroblastoma cells treated with 25 ...
Yoji Kato Kota Oki Naoko Suga Shigeki Ono Akari Ishisaka Yoko Miura Satoshi Kanazawa Michitaka Naito Noritoshi Kitamoto Anthony J. Kettle
FREE RADICAL BIOLOGY AND MEDICINE 101 500-510 2016年12月 [査読有り]
The modification of 5-hydroxyindoleacetic acid (5HIAA) by myeloperoxidase with a xanthine oxidase system was investigated by chromatographic analyses. Two major products were identified as a dimer and quinone (indoleacetate dione) of 5HIAA. The fo...
Bioscience, biotechnology, and biochemistry 80(10) 2007-13 2016年10月 [査読有り]
Lipid peroxidation products react with cellular molecules, such as DNA bases, to form covalent adducts, which are associated with aging and disease processes. Since lipid peroxidation is a complex process and occurs in multiple stages, there might...
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 64(33) 6495-6501 2016年8月 [査読有り]
Syringic acid is one of the key skeletal structures of plant-derived,chemicals. The derivatives)of syringic acid have certain biological functions. In this study, a monoclonal antibody to syringic acid-based phytochemicals, was prepared and charac...
Manuka honey is known as one of the premium honeys because of its unique property: a potent antibacterial activity. Leptosperin, methyl syringate 4-O-beta-D-gentiobioside, has been specifically identified in manuka honey. Because leptosperin is re...
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