The Keap1-Nrf2 system and autophagy are both involved in the oxidative-stress response, metabolic pathways, and innate immunity, and dysregulation of these processes is associated with pathogenic processes. However, the interplay between these two...
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging 1 35-44 2013年8月 [査読有り]
Autophagy refers to bulk degradation processes responsible for the turnover of long-lived proteins, disposal of damaged organelles, and clearance of aggregate prone proteins. Aberrant autophagy causes the formation of cytoplasmic inclusion bodies,...
Akira Nishide   Minsoo Kim   Kenji Takagi   Ai Himeno   Takahito Sanada   Chihiro Sasakawa   Tsunehiro Mizushima   
JOURNAL OF MOLECULAR BIOLOGY 425(15) 2623-2631 2013年8月 [査読有り]
Ubc13 is a ubiquitin-conjugating enzyme that plays a key role in the nuclear factor-kappa B signal transduction pathway in human diseases. The Shigella flexneri effector OspI affects inflammatory responses by catalyzing the deamidation of a specif...
Taira Kobayashi   Michinaga Ogawa   Takahito Sanada   Hitomi Mimuro   Minsoo Kim   Hiroshi Ashida   Reiko Akakura   Mitsutaka Yoshida   Magdalena Kawalec   Jean-Marc Reichhart   Tsunehiro Mizushima   Chihiro Sasakawa   
CELL HOST & MICROBE 13(5) 570-583 2013年5月 [査読有り]
Caspase-mediated inflammatory cell death acts as an intrinsic defense mechanism against infection. Bacterial pathogens deploy countermeasures against inflammatory cell death, but the mechanisms by which they do this remain largely unclear. In a sc...
JOURNAL OF BIOLOGICAL CHEMISTRY 285(20) 15159-15166 2010年5月
The ubiquitin-proteasome pathway is a major proteolytic system in eukaryotic cells and regulates various cellular processes. The 26 S proteasome, the central enzyme of this pathway, consists of a proteolytic core particle and two 19 S regulatory p...