Assembly of the eukaryotic 20S proteasome is an ordered process involving several proteins operating as proteasome assembly factors including PAC1-PAC2 but archaeal 20S proteasome subunits can spontaneously assemble into an active cylindrical arch...
HOIL-1L and its binding partner HOIP are essential components of the E3-ligase complex that generates linear ubiquitin (Ub) chains, which are critical regulators of NF-κB activation. Using crystallographic and mutational approaches, we characteriz...
Kenji Takagi Sangwoo Kim Haruka Yukii Mika Ueno Ryo Morishita Yaeta Endo Koichi Kato Keiji Tanaka Yasushi Saeki Tsunehiro Mizushima
JOURNAL OF BIOLOGICAL CHEMISTRY 287(15) 12172-12182 2012年4月 [査読有り]
The 26 S proteasome is a 2.5-MDa molecular machine that degrades ubiquitinated proteins in eukaryotic cells. It consists of a proteolytic core particle and two 19 S regulatory particles (RPs) composed of 6 ATPase (Rpt) and 13 non-ATPase (Rpn) subu...
The 26S proteasome, in collaboration with ubiquitin, operates the energy-dependent regulated proteolysis process in eukaryotic cells. Over the past 30 years, several studies have comprehensively characterized the structure and molecular/physiologi...
JOURNAL OF BIOLOGICAL CHEMISTRY 285(20) 15159-15166 2010年5月
The ubiquitin-proteasome pathway is a major proteolytic system in eukaryotic cells and regulates various cellular processes. The 26 S proteasome, the central enzyme of this pathway, consists of a proteolytic core particle and two 19 S regulatory p...
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