DRUG METABOLISM AND PHARMACOKINETICS 21(1) 70-74 2006年 [査読有り]
Expression of UDP-glucuronosyltransferases (UGT) in mammals is thought to be regulated in both a tissue- and developmental-specific manner. Furthermore, induction of genes encoding UGT occurs after exposure to xenobiotics including drugs, environm...
JOURNAL OF BIOCHEMISTRY 138(3) 313-325 2005年9月 [査読有り]
In cultured primary hepatocytes UDP-glucuronosyltransferase form 1A2 (UGT1A2) mRNA level is 80 times higher than that found in rat liver. We previously identified an enhancer sequence in the UGT1A2 promoter, and designated it as culture-associated...
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1672(2) 86-92 2004年5月
Xenobiotic Phase I and Phase II reactions in hepatocytes occur sequentially and cooperatively during the metabolism of various chemical compounds including drugs. In order to investigate the sequential metabolism of 7-ethoxycoumarin (7EC) as model...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 310(3) 735-741 2003年10月 [査読有り]
UDP-glucuronosyltransferase form 1A1 (UGT1A1) is the only bilirubin-glucuronidating isoform of this protein, and genetic deficiencies of UGT1A1 cause Crigler-Najjar syndrome, a disorder resulting from nonhemolytic unconjugated hyperbilirubinemia. ...
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理学研究科