MG Luquita VA Catania EJS Pozzi LM Veggi T Hoffman JM Pellegrino SI Ikushiro Y Emi T Iyanagi M Vore AD Mottino
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 298(1) 49-56 2001年7月 [査読有り]
The molecular basis of perinatal changes occurring in major UDP-glucuronosyltransferase (UGT) family 1 isoforms and in UGT2B1, a relevant isoform belonging to family 2, was analyzed in rat liver. Nonpregnant, pregnant (19-20 days of pregnancy), an...
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 378(2) 384-392 2000年6月
UGT1A2, an isoform of the UDP-glucuronosyltransferase family 1 (UGT1), is not expressed in the rat liver, but its expression was highly induced in primary cultures of rat hepatocytes, In primary hepatocytes that had been cultured for 70 h, the amo...
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1428(2-3) 388-396 1999年8月
Chemical modification of rat hepatic microsomes with N-ethylmaleimide (NEM) resulted in inactivation of UDP-N-acetylglucosamine (UDP-GlcNAc)-dependent stimulation of glucuronidation of p-nitrophenol. Inactivation kinetics and pH dependence were in...
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY 1430(2) 290-301 1999年3月
The cDNA encoding solubilized porcine liver NADH-cytochrome b(5) reductase catalytic domain (Pb5R) was cloned and overexpressed in Escherichia coli. A highly conserved His(49) and a C-terminal Phe(272) of Pb5R, which are located near the isoalloxa...
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1407(3) 173-184 1998年9月
Bilirubin, the oxidative product of heme in mammals, is excreted into the bile after its esterification with glucuronic acid to polar mono- and diconjugated derivatives. The accumulation of unconjugated and conjugated bilirubin in the serum is cau...
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理学研究科