Comprehensive Biotechnology, Second Edition 1 525-537 2011年9月 [査読有り]
The unfolded protein response is a regulatory mechanism that enhances the expression of proteins involved in the function of the endoplasmic reticulum (ER), including ER chaperones as well as components of ER-associated degradation, when eukaryoti...
CELL STRUCTURE AND FUNCTION 36(1) 1-12 2011年 [査読有り]
When increased production of secretory proteins overwhelms the capacity of the endoplasmic reticulum (ER) and the Golgi apparatus, eukaryotic cells expand their capacity to sustain secretory function. The capacity of the ER is enhanced by the mech...
The endoplasmic reticulum (ER) response has been thought a cytoprotective mechanism to cope with accumulation of unfolded proteins in the ER. Recent progress has made a quantum leap revealing that ER stress response can be regarded as an autoregul...
Aya Uemura   Masaya Oku   Kazutoshi Mori   Hiderou Yoshida   
JOURNAL OF CELL SCIENCE 122(16) 2877-2886 2009年8月 [査読有り]
XBP1 is a key transcription factor that regulates the mammalian unfolded protein response. Its expression is regulated by unconventional mRNA splicing that is carried out by endonuclease IRE1 and a specific, as yet unknown, RNA ligase in response ...
Hiderou Yoshida   Aya Uemura   Kazutoshi Mori   
CELL STRUCTURE AND FUNCTION 34(1) 1-10 2009年 [査読有り]
Cells from yeast to humans activate unconventional mRNA splicing when unfolded proteins accumulate in the endoplasmic reticulum (ER) under ER stress conditions. The substrate of this splicing in mammalian cells is XBP1 mRNA, which encodes the unfo...