Keisuke Yamamoto   Natsumi Suzuki   Tadashi Wada   Tetsuya Okada   Hiderou Yoshida   Randal J. Kaufman   Kazutoshi Mori   
JOURNAL OF BIOCHEMISTRY 144(4) 477-486 2008年10月 [査読有り]
Quality control of proteins in the endoplasmic reticulum (ER) is achieved by two mechanisms, the productive folding mechanism, which is assisted by a number of ER-localized molecular chaperones and folding enzymes (collectively termed ER chaperone...
Yusuke Adachi   Keisuke Yamamoto   Tetsuya Okada   Hiderou Yoshida   Akihiro Harada   Kazutoshi Mori   
CELL STRUCTURE AND FUNCTION 33(1) 75-89 2008年 [査読有り]
Eukaryotic cells cope with endoplasmic reticulum (ER) stress by activating the unfolded protein response (UPR), a coordinated system of transcriptional and translational controls, which ensures the integrity of synthesized proteins. Mammalian cell...
Cytoplasmic splicing is one of the major regulatory mechanisms of the unfolded protein response (UPR). The molecular mechanism of cytoplasmic splicing is unique and completely different from that of conventional nuclear splicing. The mammalian sub...
Keisuke Yamamoto   Takashi Sato   Toshie Matsui   Masanori Sato   Tetsuya Okada   Hiderou Yoshida   Akihiro Harada   Kazutoshi Mori   
DEVELOPMENTAL CELL 13(3) 365-376 2007年9月 [査読有り]
Metazoans express three unfolded protein response transducers (IRE1, PERK, and ATF6) ubiquitously to cope with endoplasmic reticulum (ER) stress. ATF6 is an ER membrane-bound transcription factor activated by ER stress-induced proteolysis and has ...