Satomi Nadanaka   Tetsuya Okada   Hiderou Yoshida   Kazutoshi Mori   
MOLECULAR AND CELLULAR BIOLOGY 27(3) 1027-1043 2007年2月 [査読有り]
ATF6 is a membrane-bound transcription factor activated by proteolysis in response to endoplasmic reticulum (ER) stress to induce the transcription of ER chaperone genes. We show here that, owing to the presence of intra- and intermolecular disulf...
Proteins synthesized in the endoplasmic reticulum (ER) are properly folded with the assistance of ER chaperones. Malfolded proteins are disposed of by ER-associated protein degradation (ERAD). When the amount of unfolded protein exceeds the foldin...
H Yoshida   M Oku   M Suzuki   K Mori   
JOURNAL OF CELL BIOLOGY 172(4) 565-575 2006年2月 [査読有り]
Upon the accumulation of unfolded proteins in the mammalian endoplasmic reticulum (ER), X-box binding protein 1 (XBP1) premessenger RNA (premRNA) is converted to mature mRNA by unconventional splicing that is mediated by the endonuclease inositol-...
Y Oda   T Okada   H Yoshida   RJ Kaufman   K Nagata   K Mori   
JOURNAL OF CELL BIOLOGY 172(3) 383-393 2006年1月 [査読有り]
Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. Components of both productive folding and ER-associated degradation (ERAD) mechanisms are known to be up-...